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家兔中的致畸学研究。

Teratology studies in the rabbit.

作者信息

Allais Linda, Reynaud Lucie

机构信息

Ricerca Biosciences, Saint-Germain sur l'Arbresle, France.

出版信息

Methods Mol Biol. 2013;947:139-56. doi: 10.1007/978-1-62703-131-8_12.

Abstract

The rabbit is generally the non-rodent species or second species after the rat recommended by the regulatory authorities and is part of the package of regulatory reproductive studies for the detection of potential embryotoxic and/or teratogenic effects of pharmaceuticals, chemicals, food additives, and other compounds, including vaccines (see Chapters 1-7).Its availability, practicality in housing and in mating as well as its large size makes the rabbit the preferred choice as a non-rodent species. The study protocols are essentially similar to those established for the rat (Chapter 9), with some particularities. The study designs are well defined in guidelines and are relatively standardized between testing laboratories across the world.As for the rat, large litter sizes and extensive background data in the rabbit are valuable criteria for an optimal assessment of in utero development of the embryo or fetus and for the detection of potential external or internal fetal malformations.

摘要

兔子通常是监管机构推荐的非啮齿类物种或仅次于大鼠的第二种物种,是用于检测药物、化学品、食品添加剂和其他化合物(包括疫苗,见第1 - 7章)潜在胚胎毒性和/或致畸作用的一整套监管生殖研究的一部分。兔子的可得性、饲养和交配的实用性以及其体型较大,使其成为作为非啮齿类物种的首选。研究方案基本上与为大鼠制定的方案相似(第9章),但有一些特殊性。研究设计在指南中有明确规定,并且在世界各地的检测实验室之间相对标准化。与大鼠一样,兔子的产仔数多以及广泛的背景数据对于最佳评估胚胎或胎儿的子宫内发育以及检测潜在的外部或内部胎儿畸形是有价值的标准。

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