化妆品的致畸学测试。

The teratology testing of cosmetics.

作者信息

Spézia François, Barrow Paul C

机构信息

CiToxLAB, Evreux, France.

出版信息

Methods Mol Biol. 2013;947:91-4. doi: 10.1007/978-1-62703-131-8_8.

DOI:10.1007/978-1-62703-131-8_8

PMID:23138898

Abstract

In Europe, the developmental toxicity testing (including teratogenicity) of new cosmetic ingredients is performed according to the Cosmetics Directive 76/768/EEC: only alternatives leading to full replacement of animal experiments should be used. This chapter presents the three scientifically validated animal alternative methods for the assessment of embryotoxicity: the embryonic stem cell test (EST), the micromass (MM) assay, and the whole embryo culture (WEC) assay.

摘要

在欧洲，新化妆品成分的发育毒性测试（包括致畸性）是根据欧盟化妆品指令76/768/EEC进行的：应仅使用能够完全替代动物实验的替代方法。本章介绍了三种经过科学验证的用于评估胚胎毒性的动物替代方法：胚胎干细胞试验（EST）、微团培养（MM）试验和全胚胎培养（WEC）试验。