Department of Chemistry, Wayne State University, 5101 Cass Avenue, Detroit, MI 48202, USA.
Chem Commun (Camb). 2013 May 14;49(39):4148-50. doi: 10.1039/c2cc36583a. Epub 2012 Nov 9.
A multimodal, β-amyloid-targeted contrast agent was synthesized and studied in vitro. The agent has a higher relaxivity than a clinically approved contrast agent and interacts with β-amyloid aggregates producing changes in relaxation rate and fluorescence emission.
一种多模态、靶向β-淀粉样蛋白的造影剂被合成并进行了体外研究。该造影剂的弛豫率高于临床批准的造影剂,并与β-淀粉样蛋白聚集物相互作用,导致弛豫率和荧光发射的变化。