Molecular Chemoprevention and Therapeutics, The Hormel Institute, University of Minnesota, Austin, MN 55912, USA.
Curr Drug Targets. 2012 Dec;13(14):1907-16. doi: 10.2174/138945012804545579.
Androgen is a key for the activation of Androgen Receptor (AR) in most of the disease conditions, however androgen-independent activation of AR is also found in aggressive type human malignancies. An intense search for the inhibitors of AR is underway to cure AR-dependent diseases. In addition to targeting various components of AR signaling pathway, compounds which directly target AR are under preclinical and clinical investigation. Various In vitro and preclinical animal studies suggest that different natural compounds have potential to act against AR. Some natural compounds have been found to be pharmacologically effective against AR irrespective of varying routs of administration viz; oral, intra-peritoneal and intravenous. This mini-review summarizes the studies conducted with different natural agents in determining their pharmacological utility against AR signaling.
雄激素是大多数疾病条件下激活雄激素受体 (AR) 的关键，但在侵袭性人类恶性肿瘤中也发现了雄激素非依赖性的 AR 激活。目前正在积极寻找 AR 的抑制剂，以治疗 AR 依赖性疾病。除了针对 AR 信号通路的各种成分外，直接针对 AR 的化合物也正在进行临床前和临床研究。各种体外和临床前动物研究表明，不同的天然化合物具有针对 AR 的潜力。一些天然化合物已被发现具有对抗 AR 的药理作用，而不管给药途径如何，例如口服、腹腔内和静脉内。本综述总结了使用不同天然药物进行的研究，以确定它们在对抗 AR 信号方面的药理作用。
