手性 Rh-双（恶唑啉基）苯基催化剂促进的共轭硅氢化反应对映选择性合成手性 3,3-二芳基丙酯。
Enantioselective synthesis of optically active 3,3-diarylpropanoates by conjugate hydrosilylation with chiral Rh-bis(oxazolinyl)phenyl catalysts.
机构信息
Department of Applied Chemistry, Graduate School of Engineering, Nagoya University, Chikusa, Nagoya 464-8603 Japan.
出版信息
J Org Chem. 2012 Dec 7;77(23):10914-9. doi: 10.1021/jo302357b. Epub 2012 Nov 16.
PMID:23140754
Abstract
Conjugate hydrosilylation of 3,3-diarylacrylate derivatives catalyzed by chiral rhodium-bis(oxazolinyl)phenyl complexes (1 mol %) at 60 °C for 2 h was investigated to prepare optically active 3,3-diarylpropanoate derivatives in high yields up to 99% yield and high enantioselectivities up to 99%.
摘要
手性铑-双（恶唑啉基）苯基配合物（1 mol %）催化 3,3-二芳基丙烯酸酯衍生物的共轭硅氢化反应，在 60°C 下反应 2 小时，以高产率（高达 99%）和高对映选择性（高达 99%）制备光学活性 3,3-二芳基丙酸酯衍生物。
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