An Rong Rong, Luo Xiao Sen, Shen Zhong Hua
School of Science, Nanjing University of Science and Technology, Nanjing, China.
Appl Opt. 2012 Nov 10;51(32):7869-76. doi: 10.1364/AO.51.007869.
The influence of the elastic modulus of a tumor (EMT) on the laser-generated thermoelastic force source and ultrasound waves are investigated by using the finite element method. Taking into account the effects of thermal diffusion, optical penetration, and finite duration of laser pulse, the transient temperature distribution is obtained. Applying this temperature field to structure analyses as thermal loading, the thermoelastic stress field and laser-induced ultrasound wave in soft tissues are obtained. The results show that there is a linear correlation between the maximum compressive stress and the elastic modulus of tissues. It is also shown that the features and frequency regions of the laser-induced ultrasound waveform have a close relationship with the EMT, which has been further verified by a corresponding experiment.
利用有限元方法研究了肿瘤弹性模量（EMT）对激光产生的热弹力源和超声波的影响。考虑到热扩散、光穿透和激光脉冲有限持续时间的影响，获得了瞬态温度分布。将此温度场作为热载荷应用于结构分析，得到了软组织中的热弹性应力场和激光诱导的超声波。结果表明，最大压缩应力与组织弹性模量之间存在线性相关性。还表明，激光诱导超声波形的特征和频率区域与EMT密切相关，这已通过相应实验得到进一步验证。
