Department of Chemistry, University of Southern California, Los Angeles, CA 90089-0744, USA.
Chembiochem. 2012 Dec 21;13(18):2665-70. doi: 10.1002/cbic.201200478. Epub 2012 Nov 9.
Sweet relief: the Parkinson's disease- associated protein α-synuclein is post-translationally modified by N-acetylglucosamine (O-GlcNAc), but the biochemical consequences are unknown. Here we show that an O-GlcNAc-modified peptide does not participate in α-synuclein aggregation, thus suggesting that O-GlcNAc might directly inhibit aggregation in cells.
帕金森病相关蛋白α-突触核蛋白可被 N-乙酰葡萄糖胺（O-GlcNAc）进行翻译后修饰，但生化后果尚不清楚。本文中，我们发现 O-GlcNAc 修饰肽不参与α-突触核蛋白聚集，因此表明 O-GlcNAc 可能直接抑制细胞中的聚集。
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