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西班牙一项关于心脏死亡后供体肾脏移植的新项目。

A new program of kidney transplantation from donors after cardiac death in Spain.

作者信息

de Gracia M C, Osorio J M, Pérez-Villares J M, Galindo P, Ruiz M C, Pérez-Marfil A, Bravo J, Osuna A

机构信息

Hospital Universitario Virgen de las Nieves, Grenada, Spain.

出版信息

Transplant Proc. 2012 Nov;44(9):2518-20. doi: 10.1016/j.transproceed.2012.09.040.

Abstract

Despite the high rate of kidney transplantation in Spain, a disparity still exists between the numbers of donors and waiting-list patients. Donors after circulatory death (DCD) have been propagated as a promising approach to reduce the donor kidney shortage. In Europe most of the countries use controlled DCD, but in Spain, mainly uncontrolled DCD are harvested and until 2010 at only four institutions. In January 2010, we began a program of donation after uncontrolled DCD (Maastricht type II; unsuccessful resuscitation). The aim of this observational study was to describe our preliminary results. The numbers of recovered and transplanted organs per DCD were 27. There were no cases of primary nonfunction, but delayed graft function was present in 85% of recipients. Despite this impairment, about 75% of patients reached a serum creatinine below 2 mg/dL in the second month, with 1-year graft and patient survivals of 85% and 100%. Although, our preliminary results with a not very long follow-up and small number of patients suggested that utilization of DCD should be expanded because this type of donor increases the number of cases and opportunities of end-stage renal disease patients to reduce the waiting times for transplantation.

摘要

尽管西班牙的肾脏移植率很高,但供体数量与等待名单上的患者数量之间仍存在差距。循环死亡后供体(DCD)已被推广为一种有望减少供体肾脏短缺的方法。在欧洲,大多数国家采用控制性DCD,但在西班牙,主要采集非控制性DCD,直到2010年只有四家机构开展。2010年1月,我们启动了一项非控制性DCD(马斯特里赫特II型;复苏失败)后的捐赠计划。这项观察性研究的目的是描述我们的初步结果。每个DCD回收和移植的器官数量为27个。没有原发性无功能的病例,但85%的受者出现了移植肾功能延迟。尽管存在这种损害,但约75%的患者在第二个月时血清肌酐降至2mg/dL以下,1年移植肾和患者生存率分别为85%和100%。虽然我们的初步结果随访时间不长且患者数量较少,但表明应扩大DCD的应用,因为这种类型的供体增加了病例数量以及终末期肾病患者减少移植等待时间的机会。

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