Górski A
Biomedicine. 1979 Oct;30(4):206-10.
We have demonstrated in this study that corticosteroids modify cellular interactions enhancing CSA production. This phenomenon may contribute to the leukocytosis-promoting action of these hormones, although at present it is unknown whether this mechanism is more important in vivo than steroid-dependent changes in the circulation and redistribution of phagocytic cells. The observation that corticosteroids impair phagocyte functions is difficult to reconcile with the well known fact that hypercorticism as a part of the normal body defense to stress (6). In view of our data it appears, however, that these possible detrimental effects of corticosteroids on mature white blood cells are counteracted by their stimulatory action on the production of new phagocytic cells. Such a conclusion is in accord with Joyce and Charvenick (20) who showed that those hormones enhance the return of GM-CFU in cyclophosphamide-treated mice and improve tolerance to infection.
我们在本研究中证明，皮质类固醇可改变细胞间相互作用，增强CSA的产生。这种现象可能有助于这些激素促进白细胞增多的作用，尽管目前尚不清楚该机制在体内是否比吞噬细胞在循环和重新分布方面依赖类固醇的变化更为重要。皮质类固醇会损害吞噬细胞功能这一观察结果，很难与皮质功能亢进作为机体对应激的正常防御机制的一部分这一众所周知的事实相协调（6）。然而，根据我们的数据，皮质类固醇对成熟白细胞可能产生的这些有害作用，似乎被它们对新吞噬细胞产生的刺激作用所抵消。这一结论与乔伊斯和查维尼克（20）的研究结果一致，他们表明这些激素可提高环磷酰胺处理小鼠体内GM-CFU的恢复，并提高对感染的耐受性。
