Bhagat Shaum, Bass Johnnie, Qaddoumi Ibrahim, Brennan Rachel, Wilson Matthew, Wu Jianrong, Galindo Carlos-Rodriguez, Paglialonga Alessia, Tognola Gabriella
Hearing Science Laboratory, School of Communication Sciences and Disorders, The University of Memphis, and St. Jude Children's Research Hospital, Memphis, TN 38105, USA.
Audiol Neurootol. 2013;18(2):71-82. doi: 10.1159/000343909. Epub 2012 Nov 6.
The aims of this study were to characterize and quantify time-frequency changes in transient-evoked otoacoustic emissions (TEOAEs) recorded in children diagnosed with retinoblastoma who were receiving carboplatin chemotherapy. A signal processing technique, the wavelet transform (WT), was used to analyze TEOAE waveforms in narrow-band frequency components. Ten children (aged 3-72 months) diagnosed with unilateral or bilateral retinoblastoma were enrolled in the study. TEOAEs were acquired from the children with linear sequences of 70 dB peak equivalent SPL clicks. After WT analysis, TEOAE energy, latency and normalized energy in the narrow-band frequency components were compared before and during carboplatin chemotherapy treatment (average dose 1693 mg/m2). On a group basis, no significant differences (p>0.05) in the TEOAE energy, latency or normalized energy before and after carboplatin treatment were observed. There were decreases in normalized energy on an individual basis in 10 out of 18 ears in the sample. Exposure to carboplatin chemotherapy did not cause significant changes in TEOAE energy, latency and normalized energy during treatment. However, long-term monitoring of hearing with measurements of TEOAEs is warranted, given the risks of delayed hearing loss in some children receiving carboplatin chemotherapy.
本研究的目的是对接受卡铂化疗的视网膜母细胞瘤患儿记录的瞬态诱发耳声发射（TEOAEs）的时频变化进行特征描述和量化。采用一种信号处理技术——小波变换（WT），分析窄带频率成分中的TEOAE波形。本研究纳入了10名诊断为单侧或双侧视网膜母细胞瘤的儿童（年龄3 - 72个月）。通过70 dB峰值等效声压级短声的线性序列采集这些儿童的TEOAEs。经过WT分析，比较了卡铂化疗治疗前和治疗期间（平均剂量1693 mg/m²）窄带频率成分中的TEOAE能量、潜伏期和归一化能量。在组水平上，未观察到卡铂治疗前后TEOAE能量、潜伏期或归一化能量有显著差异（p>0.05）。样本中18只耳朵中有10只耳朵的归一化能量在个体水平上有所下降。接受卡铂化疗在治疗期间并未导致TEOAE能量、潜伏期和归一化能量发生显著变化。然而，鉴于一些接受卡铂化疗的儿童存在迟发性听力损失的风险，有必要通过测量TEOAEs对听力进行长期监测。
