Hagen C, Lindholm J, Suenson E, Riishede J, Hummer L, Jacobsen H H
Clin Endocrinol (Oxf). 1979 Dec;11(6):671-9. doi: 10.1111/j.1365-2265.1979.tb03123.x.
The influence of hyperprolactinaemia on endocrine functions in forty-two consecutive patients with untreated pituitary tumours was studied. Patients with acromegaly, Cushing's disease and Nelson's syndrome were excluded. Sixteen patients (eleven men and five women) had a pituitary adenoma with suprasellar extension and twenty-six (eleven men and fifteen women) had a small intrasellar tumour. Basal plasma prolactin concentration was measured in all. Thyroid function was assessed by plasma thyroxine (T4) and TSH concentrations, adrenocortical function and growth hormone (GH) secretion by the maximum plasma cortisol, adrenocorticotrophin (ACTH) and GH concentrations, respectively, during insulin-induced hypoglycaemia (tITT). Gonadal function was studied by measuring plasma concentrations of luteinizing hormone (LH), follicle stimulating hormone (FSH), oestradiol-17 beta and in men, testosterone. On the basis of computer assisted tomography of the sella turcica, the tumour volume was calculated. The basal plasma prolactin concentration was elevated in 69% of the patients. Decreased GH secretion was the most frequent pituitary dysfunction (78%) followed in men by gonadal insufficiency (77%), adrenocortical insufficiency (31%) and thyroid insufficiency (21%). There was no difference between patients with elevated and normal plasma prolactin concentration as to the tumour volume and any of the endocrine variables.
对42例未经治疗的垂体瘤患者进行了高催乳素血症对内分泌功能影响的研究。肢端肥大症、库欣病和尼尔森综合征患者被排除在外。16例患者（11名男性和5名女性）患有鞍上扩展的垂体腺瘤，26例（11名男性和15名女性）患有小的鞍内肿瘤。对所有患者均测定了基础血浆催乳素浓度。通过血浆甲状腺素（T4）和促甲状腺激素（TSH）浓度评估甲状腺功能，通过胰岛素诱发低血糖症（tITT）期间的最大血浆皮质醇、促肾上腺皮质激素（ACTH）和生长激素（GH）浓度分别评估肾上腺皮质功能和生长激素（GH）分泌。通过测量血浆促黄体生成素（LH）、促卵泡激素（FSH）、雌二醇-17β浓度以及男性的睾酮浓度来研究性腺功能。根据蝶鞍的计算机断层扫描计算肿瘤体积。69%的患者基础血浆催乳素浓度升高。生长激素分泌减少是最常见的垂体功能障碍（78%），男性其次是性腺功能不全（77%）、肾上腺皮质功能不全（31%）和甲状腺功能不全（21%）。血浆催乳素浓度升高和正常的患者在肿瘤体积和任何内分泌变量方面均无差异。
