Akçay G, Aral F, Ozbey N, Azezli A, Orhan Y, Sencer E, Molvalilar S
Department of Internal Medicine, School of Medicine, Instanbul University, Turkey.
J Int Med Res. 1996 Mar-Apr;24(2):221-7. doi: 10.1177/030006059602400207.
Long-standing primary failure of pituitary-dependent endocrine glands may lead to hyperplasia of the pituitary cells. These changes in the pituitary gland may be correlated with the severity and duration of target-endocrine gland insufficiency. Production of adrenocorticotrophic hormone by the pituitary tumour and modest hyperprolactinaemia may develop due to adrenocortical insufficiency, but production of prolactin by the pituitary tumour due to primary adrenal insufficiency is rare. A case study is presented, with primary adrenal insufficiency associated with hyperprolactinaemia and pituitary macroadenoma (most probably prolactinoma). Plasma levels of prolactin were found to decrease after glucocorticoid, mineralocorticoid and bromocriptine therapy.
长期存在的垂体依赖性内分泌腺原发性功能衰竭可能导致垂体细胞增生。垂体的这些变化可能与靶内分泌腺功能不全的严重程度和持续时间相关。垂体肿瘤产生促肾上腺皮质激素以及由于肾上腺皮质功能不全可能出现轻度高泌乳素血症，但原发性肾上腺功能不全导致垂体肿瘤产生泌乳素的情况较为罕见。本文介绍了一例原发性肾上腺功能不全伴高泌乳素血症和垂体大腺瘤（很可能是泌乳素瘤）的病例。糖皮质激素、盐皮质激素和溴隐亭治疗后，血浆泌乳素水平降低。
