磷脂酰肌醇途径与神经发育中的信号转导网络。
Phosphoinositide pathway and the signal transduction network in neural development.
机构信息
Department Organi di Senso, Policlinico Umberto I, Faculty of Medicine, Sapienza University of Rome, viale del Policlinico 33, Rome 00185, Italy.
出版信息
Neurosci Bull. 2012 Dec;28(6):789-800. doi: 10.1007/s12264-012-1283-x. Epub 2012 Nov 14.
Abstract
The development of the nervous system is under the strict control of a number of signal transduction pathways, often interconnected. Among them, the phosphoinositide (PI) pathway and the related phospholipase C (PI-PLC) family of enzymes have been attracting much attention. Besides their well-known role in the regulation of intracellular calcium levels, PI-PLC enzymes interact with a number of molecules belonging to further signal transduction pathways, contributing to a specific and complex network in the developing nervous system. In this review, the connections of PI signalling with further transduction pathways acting during neural development are discussed, with special regard to the role of the PI-PLC family of enzymes.
摘要
神经系统的发育受到许多信号转导途径的严格控制，这些途径通常相互关联。其中，磷酸肌醇（PI）途径和相关的磷脂酶 C（PI-PLC）酶家族引起了广泛关注。除了在调节细胞内钙离子水平方面的众所周知的作用外，PI-PLC 酶还与属于进一步信号转导途径的许多分子相互作用，为发育中的神经系统中的特定和复杂网络做出贡献。在本文综述中，讨论了 PI 信号与在神经发育过程中起作用的进一步转导途径的联系，特别关注了 PI-PLC 酶家族的作用。
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