Corona G L, Cucchi M L, Frattini P, Santagostino G, Schinelli S, Zerbi F, Savoldi F
Institute of Pharmacology, University of Pavia, Italy.
Psychopharmacology (Berl). 1990;100(3):334-8. doi: 10.1007/BF02244602.
Fifty-nine depressed female inpatients were treated with 100 mg amitriptyline (AMT) IM for 4 weeks. Depression ratings and determinations of the parent drug and nortriptyline (NT) were performed weekly. No direct relationship between plasma AMT + NT concentrations and therapeutic response was apparent, but beneficial therapeutic responses and significantly lower side-effect scores were more frequently noted in subjects with concentrations in the 100-200 ng/ml range. AMT + NT concentrations were significantly correlated with age. No significant difference was found in the number of responders between younger and older subjects with two clinical improvement criteria; however, a significant difference emerged when a third more restrictive clinical outcome criterion was adopted. The implications of the present findings for patient treatment and for the interpretation of previous studies are discussed. The data collected point to a possible usefulness of monitoring AMT and NT plasma levels, even if further investigations are needed.
59名患有抑郁症的女性住院患者接受了为期4周的100毫克阿米替林（AMT）肌肉注射治疗。每周进行抑郁评分以及母体药物和去甲替林（NT）的测定。血浆AMT + NT浓度与治疗反应之间没有明显的直接关系，但在浓度范围为100 - 200 ng/ml的受试者中，更频繁地观察到有益的治疗反应和显著更低的副作用评分。AMT + NT浓度与年龄显著相关。根据两项临床改善标准，年轻和老年受试者的反应者数量没有显著差异；然而，当采用第三个更严格的临床结果标准时，出现了显著差异。讨论了本研究结果对患者治疗和先前研究解释的意义。收集的数据表明监测AMT和NT血浆水平可能有用，尽管还需要进一步研究。
