Monteleone P, Fabrazzo M
Institute of Psychiatry, First Medical School, University of Naples, Italy.
Pharmacopsychiatry. 1994 Nov;27(6):238-41. doi: 10.1055/s-2007-1014311.
Steady-state plasma levels of mianserin, amitriptyline, and nortriptyline were determined by HPLC in two groups of elderly depressed patients who underwent a 5-week treatment with mianserin (60 mg/day in three oral doses) or amitriptyline (75 mg/day in three oral doses). Both treatments proved to be effective in reducing depressive symptoms. In the mianserin group, responder patients had steady-state plasma concentrations of mianserin higher than nonresponders. No relationship was found between amitriptyline, nortriptyline, or amitriptyline+nortriptyline plasma levels and clinical response in amitriptyline treated patients.
通过高效液相色谱法（HPLC）测定了两组老年抑郁症患者米安色林、阿米替林和去甲替林的稳态血浆水平。这两组患者分别接受为期5周的米安色林（每日60毫克，分三次口服）或阿米替林（每日75毫克，分三次口服）治疗。两种治疗方法均被证明对减轻抑郁症状有效。在米安色林组中，有反应的患者米安色林的稳态血浆浓度高于无反应者。在接受阿米替林治疗的患者中，未发现阿米替林、去甲替林或阿米替林+去甲替林的血浆水平与临床反应之间存在关联。
