Zaritskiĭ A R, Prokopenko G A, Fok M V, Iarmonenko S P
Radiobiologiia. 1990 Jan-Feb;30(1):88-93.
A hypothesis is reported postulating that the range within which the intracellular oxygen content varies with changes in the external oxygenation conditions is responsible for the oxygen-dependent radiosensitivity modification that may be controlled by the diffusion resistance of a cytoplasmic membrane. The adaptation mechanism of intracellular Po2 autoregulation is involved when drastic changes in the oxygen content of the environment occur. As the oxygen content decreases this mechanism provides maximal values of the intracellular Po2 required for optimizing cell viability; the increased oxygen content prevents cells from oxygen intoxication.
据报道提出了一种假说，即细胞内氧含量随外部氧合条件变化的范围是氧依赖性放射敏感性改变的原因，这种改变可能受细胞质膜扩散阻力的控制。当环境中的氧含量发生剧烈变化时，细胞内Po2自动调节的适应机制就会起作用。随着氧含量降低，这种机制会提供优化细胞活力所需的细胞内Po2的最大值；氧含量增加则可防止细胞发生氧中毒。
