Denays R, Tondeur M, Toppet V, Ham H, Piepsz A, Spehl M, Rubinstein M, Noel P
Department of Neurology, St. Pierre Hospital, Free Universities of Brussels, Belgium.
Radiology. 1990 Apr;175(1):111-6. doi: 10.1148/radiology.175.1.2315468.
The outlook for children with cerebral palsy is determined by the severity of motor problems and the presence of associated disabilities, in which early detection remains a medical challenge. The authors studied 13 children (aged 13 months to 12 years) with cerebral palsy by means of single photon emission computed tomography (SPECT) of the brain with technetium-99m hexamethylpropyleneamineoxime (HMPAO). In all children with hemiplegia, SPECT demonstrated hypoperfusion in the hemisphere contralateral to the motor deficit. SPECT demonstrated normal findings in patients with mild diplegia; bilateral hypoperfusion in the superior motor cortex in patients with moderate di- or tetraplegia; and bilateral reduction of perfusion in the superior motor, inferior motor, prefrontal, and parietal cortices in patients with severe di- or tetraplegia. Results suggest that Tc-99m HMPAO SPECT of the brain is a valuable complementary tool for thorough neurologic assessment in cerebral palsy.
脑瘫患儿的预后取决于运动问题的严重程度以及是否存在相关残疾，其中早期检测仍是一项医学挑战。作者通过使用锝-99m六甲基丙烯胺肟（HMPAO）进行脑单光子发射计算机断层扫描（SPECT），对13例年龄在13个月至12岁之间的脑瘫患儿进行了研究。在所有偏瘫患儿中，SPECT显示运动功能缺损对侧半球灌注不足。SPECT在轻度双瘫患儿中显示正常结果；中度双瘫或四肢瘫患儿的上运动皮层出现双侧灌注不足；重度双瘫或四肢瘫患儿的上运动、下运动、前额叶和顶叶皮层灌注均减少。结果表明，脑Tc-99m HMPAO SPECT是脑瘫全面神经学评估的一种有价值的辅助工具。
