儿童自身免疫性甲状腺炎早期补充硒的效果：一项开放标签的试点研究。

Effects of selenium supplementation in the early stage of autoimmune thyroiditis in childhood: an open-label pilot study.

作者信息

Onal Hasan, Keskindemirci Gonca, Adal Erdal, Ersen Atilla, Korkmaz Orhan

机构信息

Division of Endocrinology, Department of Pediatrics, Bakirköy Maternity and Children Education Hospital, Ministry of Health, Istanbul, MD, Turkey.

出版信息

J Pediatr Endocrinol Metab. 2012;25(7-8):639-44. doi: 10.1515/jpem-2012-0078.

DOI:10.1515/jpem-2012-0078

PMID:23155687

Abstract

AIM

The aim of the study was to evaluate the role of selenium (Se) in childhood autoimmune thyroiditis regarding its effect on thyroid-stimulating hormone (TSH), free thyroxine (fT4), thyroid peroxidase antibodies (TPOAb), thyroglobulin antibody (TgAb), and thyroid morphology.

METHODS

Newly diagnosed 23 euthyroid children (mean age, 12.3 +/- 2.4 years) with Hashimoto thyroiditis (HT) received only 50 microg L-selenomethionine per day for 3 months. The baseline basal urinary iodine level, serum Se, TSH, fT4, TPOAb, and TgAb concentrations, and thyroid morphology by ultrasound were detected. We reanalyzed the TPOAb and TgAb changes at the 3rd month and then compared the thyroid morphology with 30 healthy individuals (mean age, 12.1 +/- 2.1 years) at the 6th month.

RESULTS

Serum TPOAb, TgAb, and thyroid echogenicity were unchanged with Se supplementation. A prominent decrease in thyroid volume was noteworthy; 35% of patients showed a thyroid volume regression rate of > or = 30%.

CONCLUSION

In terms of TPOAb and TgAb, Se may not benefit in the euthyroid period of HT, but Se supplementation seems to lead a favorable response in thyroid volume regression.

摘要

目的

本研究旨在评估硒（Se）在儿童自身免疫性甲状腺炎中对促甲状腺激素（TSH）、游离甲状腺素（fT4）、甲状腺过氧化物酶抗体（TPOAb）、甲状腺球蛋白抗体（TgAb）及甲状腺形态的作用。

方法

23例新诊断为甲状腺功能正常的桥本甲状腺炎（HT）患儿（平均年龄12.3±2.4岁），每天仅接受50微克L-硒代蛋氨酸治疗，持续3个月。检测基线基础尿碘水平、血清硒、TSH、fT4、TPOAb和TgAb浓度，以及通过超声检测甲状腺形态。在第3个月时重新分析TPOAb和TgAb的变化，然后在第6个月时将甲状腺形态与30名健康个体（平均年龄12.1±2.1岁）进行比较。