Yu Chenjie, Cui Xinyan, Gu Yajun, Lu Ling, Zhu Guangjie, Chen Feng, Li Tongmei, Gao Xia
Department of Otorinolaryngology, the Affiliated Drum Tower Hospital, Medical School of Nanjing University, Nanjing, 210028, China.
Lin Chuang Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2012 Jul;26(14):647-50.
To study the risk factors and interaction of nasal septal perforation (NSP) in rats.
Animals (n=120) that underwent unilateral nasal obstruction using Merocel nasal packing or gelfoam with/without standard staphylococcus aureus inoculation were observed for the formation of NSP at 2, 3, 5, and 7 days after operation by endoscope system. Following sacrifice at 7 days, the obtained nasal secretions were prepared for bacterial culture. Experimental interventions were compared with normal controls (n=10).
Perforation of nasal septum was observed in 80% of the animals accepted nasal obstruction using Merocel nasal packing with standard staphylococcus aureus inoculation in 3 days (P < 0.01), while in 70% of those using abacterial Merocel nasal packing in 5 days (P < 0.05) and no significant difference than that of before (P > 0.05). There was a weak region in anteroinferior nasal septum in rats, which the almost NSPs located in. The position of NSP does not overlap Merocel.
The interaction of risk factors contributes to NSP. The occurrence of NSP mainly depends on the construction of nasal septum, while dysaemia is also necessary. Obstruction of nasal drainage and infection promote the development of NSP.
研究大鼠鼻中隔穿孔（NSP）的危险因素及相互作用。
将120只动物采用美洛赛鼻腔填塞物或明胶海绵进行单侧鼻腔阻塞，伴或不伴标准金黄色葡萄球菌接种，术后2、3、5和7天通过内镜系统观察NSP的形成情况。7天后处死动物，取鼻腔分泌物进行细菌培养。将实验干预组与正常对照组（n = 10）进行比较。
在接受美洛赛鼻腔填塞物并接种标准金黄色葡萄球菌的动物中，80%在3天内出现鼻中隔穿孔（P < 0.01），而在使用无菌美洛赛鼻腔填塞物的动物中，70%在5天内出现穿孔（P < 0.05），与术前相比无显著差异（P > 0.05）。大鼠鼻中隔前下区域存在一个薄弱区，几乎所有NSP均位于此。NSP的位置与美洛赛不重叠。
危险因素的相互作用导致NSP。NSP的发生主要取决于鼻中隔的结构，同时贫血也是必要条件。鼻引流受阻和感染促进NSP的发展。
