未明确宫内妊娠囊的妇女使用低剂量米非司酮和阴道米索前列醇行早期药物流产的效果。

Effectiveness of early medical abortion using low-dose mifepristone and buccal misoprostol in women with no defined intrauterine gestational sac.

机构信息

Marie Stopes International Australia, PO Box 1635, Melbourne VIC 3001, Australia.

出版信息

Contraception. 2013 Jun;87(6):855-8. doi: 10.1016/j.contraception.2012.10.013. Epub 2012 Nov 15.

DOI:10.1016/j.contraception.2012.10.013

PMID:23158804

Abstract

BACKGROUND

The study was conducted to assess the effectiveness of early medical abortion (EMA) in women with early pregnancy and no defined intrauterine gestational sac (IUGS) on ultrasound.

STUDY DESIGN

Retrospective, multicenter, observational study of oral mifepristone 200 mg and buccal misoprostol 800 mcg administered 24-48 h later for EMA (gestations ≤ 63 days). Odds ratios (ORs) [95% confidence intervals (CIs)] of EMA failure and continuing pregnancy for women with no defined IUGS vs. those with confirmed IUGS were calculated.

RESULTS

Women with no defined IUGS were more likely to experience EMA failure [9.0% (6/67) vs. 3.5% (465/13,345); OR (95% CI)=2.72 (1.17-6.33), p=.041] and continuing pregnancy [7.5% (5/67) vs. 0.6% (83/13,345); OR (95% CI)=12.72 (4.98-32.46), p<.001].

CONCLUSION

EMA failure is more likely in women with early pregnancy and no defined IUGS than those with gestations ≤ 63 days and confirmed IUGS.

摘要

背景

本研究旨在评估对于超声未见明确宫内妊娠囊（IUGS）的早期妊娠妇女，行早期药物流产（EMA）的有效性。

研究设计

这是一项回顾性、多中心、观察性研究，对口服米非司酮 200mg 联合 24-48 小时后舌下含服米索前列醇 800μg 用于 EMA（妊娠≤63 天）。计算未见明确 IUGS 与确认 IUGS 的妇女 EMA 失败和继续妊娠的比值比（OR）[95%置信区间（CI）]。

结果

未见明确 IUGS 的妇女 EMA 失败的可能性更高[9.0%（6/67）vs. 3.5%（465/13345）；OR（95%CI）=2.72（1.17-6.33），p=.041]和继续妊娠[7.5%（5/67）vs. 0.6%（83/13345）；OR（95%CI）=12.72（4.98-32.46），p<.001]。