缺血性心脏病中的血小板5-羟色胺能机制。
Platelet serotonergic mechanisms in ischaemic heart disease.
作者信息
Puri V K, Verma M, Saxena A K, Shanker K
机构信息
Department of Cardiology, Pharmacology and Therapeutics, King George's Medical College, Lucknow, India.
出版信息
Thromb Res. 1990 Feb 1;57(3):445-51. doi: 10.1016/0049-3848(90)90260-j.
The uptake, basal content and efflux of serotonin (5-HT) from the platelets of patients of ischaemic heart disease (I.H.D.) was studied and compared with normal platelets. A significant increase in uptake and basal content of 5-HT as well as increase in 5-HT efflux was observed as compared to control. Our data indicate that I.H.D. is associated with platelet serotonergic dysfunction which seems to indicate that the platelets are preactivated in I.H.D.
研究了缺血性心脏病（I.H.D.）患者血小板中5-羟色胺（5-HT）的摄取、基础含量和流出情况，并与正常血小板进行了比较。与对照组相比，观察到5-HT的摄取和基础含量显著增加，以及5-HT流出增加。我们的数据表明，缺血性心脏病与血小板5-羟色胺能功能障碍有关，这似乎表明在缺血性心脏病中血小板被预先激活。
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