Neurology Unit, Department of Medicine, Faculty of Medicine, Prince of Songkla University, Hat Yai, Songkhla 90110, Thailand.
Seizure. 2013 Mar;22(2):103-8. doi: 10.1016/j.seizure.2012.10.013. Epub 2012 Nov 16.
We investigated the influence of the CYP2C9 polymorphism on the lipid profile, insulin resistance, and subclinical atherosclerosis in young epileptic patients.
We performed a cross-sectional study to evaluate the association between CYP2C9 polymorphism and lipid profile, glucose homeostasis, and subclinical atherosclerosis in young epileptic patients via the ankle brachial index.
The frequencies of CYP2C91 (CYP2C9 wild type gene) and CYP2C93 (CYP2C9 polymorphism gene) were 75% and 25%, respectively. The mean serum total triglyceride and LDL levels were significantly higher in the wild type gene subjects than in the CYP 2C9 polymorphism gene subjects. Also, the CYP 2C9 polymorphism had marginally significant lower mean serum HDL levels than the wild type gene subjects. No patients with CYP 2C9 polymorphism gene had elevated fasting blood sugar, and insulin resistance was found in only 10 of the 75 subjects. The mean ABI was statistically significantly lower in the wild type subjects than in the CYP2C9 polymorphism gene subjects.
Our study indicates that young epileptic patients with the CYP2C9 polymorphism gene have a low risk of subclinical atherosclerosis.
我们研究了 CYP2C9 多态性对年轻癫痫患者血脂谱、胰岛素抵抗和亚临床动脉粥样硬化的影响。
我们进行了一项横断面研究，通过踝臂指数评估 CYP2C9 多态性与年轻癫痫患者血脂谱、糖代谢和亚临床动脉粥样硬化之间的关系。
CYP2C91（CYP2C9 野生型基因）和 CYP2C93（CYP2C9 多态性基因）的频率分别为 75%和 25%。野生型基因患者的血清总甘油三酯和 LDL 水平明显高于 CYP2C9 多态性基因患者。此外，CYP2C9 多态性患者的血清 HDL 水平也明显低于野生型基因患者。没有 CYP2C9 多态性基因患者的空腹血糖升高，只有 75 名患者中的 10 名存在胰岛素抵抗。野生型基因患者的平均 ABI 明显低于 CYP2C9 多态性基因患者。
我们的研究表明，携带 CYP2C9 多态性基因的年轻癫痫患者发生亚临床动脉粥样硬化的风险较低。
