Neonatal and Intensive Care Department, Warsaw Medical University, Warsaw, Poland.
Adv Med Sci. 2012;57(2):348-55. doi: 10.2478/v10039-012-0050-6.
The aim of this study was to determine brain oxygenation in full-term and preterm neonates using near infrared spectroscopy.
A total of 88 full-term and preterm newborn infants without hypoxic-ischaemic disorders admitted to the NICU were examined using NIRS on the first day of life and on day 28 of life. Additional measurements were taken at the end of the first week of life in the premature neonates group. Measurements of oxyhaemoglobin (HbO2), deoxyhaemoglobin (Hb), total haemoglobin (HbT) concentration and tissue oxygen saturation (Ox) were performed in 5 brain regions. Right and left frontal areas, the occipital area and right and left temporal areas were measured.
In full-term healthy neonates a marked decrease in HbO, Hb and HbT values was observed on day 28 of life in all brain regions except the occipital area. In the neonatal period the greatest changes in brain oxygenation occurred in the right and left frontal regions of the brain. In preterm neonates constant values of HbO2 and Ox were observed in the first 28 days of life. In preterm newborn infants, as well as in full term newborn infants, similar Ox and HbO2 values were obtained on day 28 of life.
NIRS is a safe method and can be used to evaluate brain oxygenation in newborn infants. The results of these measurements are in accordance with changes in brain oxygenation in the first month of life, which are predicated on the basis of the neonate's physiology.
本研究旨在使用近红外光谱法测定足月和早产儿的脑氧合。
共对 88 例无缺氧缺血性疾病的足月和早产儿新生儿在出生第 1 天和第 28 天进行 NIRS 检查。在早产儿组中，在生命的第一周结束时进行了额外的测量。在 5 个脑区测量氧合血红蛋白 (HbO2)、脱氧血红蛋白 (Hb)、总血红蛋白 (HbT) 浓度和组织氧饱和度 (Ox)。测量右额区、左额区、枕区和右颞区、左颞区。
在健康的足月新生儿中，除枕区外，所有脑区的 HbO2、Hb 和 HbT 值在出生第 28 天明显下降。在新生儿期，大脑氧合的最大变化发生在大脑的右额区和左额区。在早产儿中，在生命的前 28 天观察到 HbO2 和 Ox 的恒定值。在早产儿和足月儿中，在第 28 天获得了相似的 Ox 和 HbO2 值。
NIRS 是一种安全的方法，可用于评估新生儿的脑氧合。这些测量结果与新生儿生理学基础上生命的第一个月内脑氧合的变化一致。
