Zhuo Shuangmu, Zhu Xiaoqin, Chen Jianxin, Xie Shusen
Key Laboratory of OptoElectronic Science and Technology for Medicine of Ministry of Education, Fujian Provincial Key Laboratory for Photonics Technology, Institute of Laser and Optoelectronics Technology, Fujian Normal University, Fuzhou, P. R. China.
Scanning. 2013 Jul-Aug;35(4):273-6. doi: 10.1002/sca.21062. Epub 2012 Nov 15.
Collagen change is a major feature in the photoaged human skin. Here, we present the use of intrinsic second harmonic generation (SHG) signal as a novel means to quantify collagen change with photoaging. We obtain the SHG images of the superficial dermis from ex vivo the cheek skin and the abdomen skin of eight patients aged 55-60 years. The results show that SHG signal can quantitatively reveal collagen change between normal and photoaged human skin in three dimensions. By comparing normal with photoaged dermis, there are significant differences in the collagen content and fine structure, providing substantial potential to be applied in vivo for the clinical diagnosis of human skin photoaging.
胶原蛋白变化是光老化人类皮肤的一个主要特征。在此，我们展示了利用固有二次谐波产生（SHG）信号作为一种量化光老化过程中胶原蛋白变化的新方法。我们从8名年龄在55 - 60岁患者的离体脸颊皮肤和腹部皮肤获取了浅表真皮的SHG图像。结果表明，SHG信号能够在三维空间定量揭示正常和光老化人类皮肤之间的胶原蛋白变化。通过比较正常真皮和光老化真皮，胶原蛋白含量和精细结构存在显著差异，这为其在人体皮肤光老化临床诊断的体内应用提供了巨大潜力。
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