MT2-MMP 在早期鸟类形态发生过程中的表达。
MT2-MMP expression during early avian morphogenesis.
机构信息
Department of Biology, Creighton University, Omaha, Nebraska, USA.
出版信息
Anat Rec (Hoboken). 2013 Jan;296(1):64-70. doi: 10.1002/ar.22618. Epub 2012 Nov 15.
Abstract
Membrane-type 2 matrix metalloproteinase (MT2-MMP; also called MMP15) is a membrane-bound protease that degrades extracellular matrix and activates proMMPs such as proMMP-2. MMP-2 expression in avian embryos is well documented, but it is not clear how proMMP-2 is activated during avian embryogenesis. Herein, we report that MT2-MMP mRNA is expressed in several tissues including the neural folds and epidermal ectoderm, intermediate mesoderm, pharyngeal arches, limb buds, and dermis. Several, but not all, of these tissues are known to express MMP-2. These observations suggest MT2-MMP may play a role during embryonic development not only through its own proteolytic activity but also by activating proMMP-2.
摘要
膜型 2 基质金属蛋白酶（MT2-MMP；也称为 MMP15）是一种膜结合蛋白酶，可降解细胞外基质并激活 proMMPs，如 proMMP-2。禽胚中 MMP-2 的表达已有详细记载，但 proMMP-2 在禽类胚胎发生过程中如何被激活尚不清楚。在此，我们报告 MT2-MMP mRNA 在包括神经褶和表皮外胚层、中胚层、咽弓、肢芽和真皮在内的几种组织中表达。这些组织中已知有几种（但不是全部）表达 MMP-2。这些观察结果表明，MT2-MMP 不仅可以通过自身的蛋白水解活性，还可以通过激活 proMMP-2，在胚胎发育过程中发挥作用。
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