用于 T1 磁共振成像对比剂的超小、均匀、单 bcc 相 Fe(x)Co(1-x)/石墨壳纳米晶体。

Ultra-small, uniform, and single bcc-phased Fe(x)Co(1-x)/graphitic shell nanocrystals for T1 magnetic resonance imaging contrast agents.

机构信息

Department of Chemistry and Inorganic and Bio-Materials Center of BK21, Sogang University, Seoul, 121-742, Korea.

出版信息

Chem Asian J. 2013 Jan;8(1):290-5. doi: 10.1002/asia.201200950. Epub 2012 Nov 14.

DOI:10.1002/asia.201200950

Abstract

We have synthesized ultra-small and uniform Fe(x)Co(1-x)/graphitic carbon shell (Fe(x)Co(1-x)/GC) nanocrystals (x=0.13, 0.36, 0.42, 0.50, 0.56, and 0.62, respectively) with average diameters of <4 nm by thermal decomposition of metal precursors in approximately 60 nm MCM-41 and methane CVD. The composition of the Fe(x)Co(1-x)/GC nanocrystals can be tuned by changing the Fe:Co ratios of the metal precursors. The Fe(x)Co(1-x)/GC nanocrystals show superparamagnetic properties at room temperature. The Fe(0.50)Co(0.50)/GC, Fe(0.56)Co(0.44)/GC, and Fe(0.62)Co(0.38)/GC nanocrystals have a single bcc FeCo structure, whereas the Fe(0.13)Co(0.87)/GC, Fe(0.36)Co(0.64)/GC, and Fe(0.42)Co(0.58)/GC nanocrystals have a mixed structure of bcc FeCo and fcc Co. The single bcc-phased Fe(x)Co(1-x)/GC nanocrystals functionalized with phospholipid-poly(ethylene glycol) (PL-PEG) in phosphate buffered saline (PBS) are demonstrated to be excellent T(1) MRI contrast agents.

摘要

我们通过在大约 60nm 的 MCM-41 中和甲烷 CVD 中热分解金属前驱体，合成了平均直径小于 4nm 的超小且均匀的 Fe(x)Co(1-x)/石墨碳壳 (Fe(x)Co(1-x)/GC) 纳米晶体（x=0.13、0.36、0.42、0.50、0.56 和 0.62，分别）。通过改变金属前驱体的 Fe:Co 比，可以调整 Fe(x)Co(1-x)/GC 纳米晶体的组成。Fe(x)Co(1-x)/GC 纳米晶体在室温下表现出超顺磁性。Fe(0.50)Co(0.50)/GC、Fe(0.56)Co(0.44)/GC 和 Fe(0.62)Co(0.38)/GC 纳米晶体具有单一的 bcc FeCo 结构，而 Fe(0.13)Co(0.87)/GC、Fe(0.36)Co(0.64)/GC 和 Fe(0.42)Co(0.58)/GC 纳米晶体具有 bcc FeCo 和 fcc Co 的混合结构。在磷酸盐缓冲盐水 (PBS) 中用磷脂聚乙二醇 (PL-PEG) 功能化的具有单一 bcc 相的 Fe(x)Co(1-x)/GC 纳米晶体被证明是优异的 T(1) MRI 造影剂。