肿瘤代谢：从质谱蛋白质组分析中学到的知识。
Cancer metabolism: what we can learn from proteomic analysis by mass spectrometry.
机构信息
Center for Applied Proteomics and Molecular Medicine, George Mason University, 10900 University Blvd, MS 1A9, Manassas, VA 20110, USA.
出版信息
Cancer Genomics Proteomics. 2012 Nov;9(6):373-81.
Abstract
A variety of genomic and proteomic tools have been used to study cancer metabolism and metabolomics in order to understand how cancer cells survive in their environment. Throughout the past decade, mass spectrometry has been routinely used for large-scale protein identification of complex biological mixtures. In this review, we discuss some recent developments in cancer metabolism by proteomic analysis using mass spectrometric techniques, focusing on pyruvate kinase, L-lactate dehydrogenase, Warburg effect, glutamine metabolism and oxidative stress.
摘要
已经使用了各种基因组学和蛋白质组学工具来研究癌症代谢和代谢组学，以了解癌细胞如何在其环境中存活。在过去的十年中，质谱已被常规用于大规模鉴定复杂生物混合物中的蛋白质。在本文中，我们通过使用质谱技术的蛋白质组学分析讨论了癌症代谢的一些最新进展，重点介绍了丙酮酸激酶、L-乳酸脱氢酶、瓦博格效应、谷氨酰胺代谢和氧化应激。
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