Key Laboratory of Molecular Medicine, Ministry of Education, Department of Biochemistry and Molecular Biology, Shanghai Medical College, Fudan University, Shanghai 200032, China.
Acta Biochim Biophys Sin (Shanghai). 2014 Mar;46(3):204-13. doi: 10.1093/abbs/gmt154. Epub 2014 Jan 30.
Metabolic reprogramming is one of the critical features in cancer. Tumor cells preferentially utilize glycolysis instead of oxidative phosphorylation in the presence of oxygen, namely 'Warburg Effect'. Recent studies have provided new insights into the Warburg effect, elucidating metabolic-dependent and independent mechanisms of metabolic enzymes regulated by post-translational modifications and providing further evidence for the critical role of these tricks in cancer metabolism and tumorigenesis. Of particular interest, we summarized the latest advances in both the metabolic and the non-metabolic functions of metabolic enzymes via the acetylation regulation in the Warburg effect. In addition, their potential roles in cancer metabolism therapy will also be briefly discussed.
代谢重编程是癌症的关键特征之一。在氧存在的情况下，肿瘤细胞优先利用糖酵解而不是氧化磷酸化，即“瓦堡效应”。最近的研究为瓦堡效应提供了新的见解，阐明了代谢酶的代谢依赖和独立的机制，这些机制受翻译后修饰的调节，并为这些策略在癌症代谢和肿瘤发生中的关键作用提供了进一步的证据。特别值得关注的是，我们总结了通过瓦堡效应中的乙酰化调节，代谢酶的代谢和非代谢功能的最新进展。此外，还将简要讨论它们在癌症代谢治疗中的潜在作用。
