顶点差异化二十面体 closo-硼烷的合成：用于靶向药物递送的多功能支架。
Synthesis of vertex-differentiated icosahedral closo-boranes: polyfunctional scaffolds for targeted drug delivery.
机构信息
International Institute of Nano and Molecular Medicine, School of Medicine, University of Missouri, Columbia, Missouri 65211-3450, USA.
出版信息
J Org Chem. 2012 Dec 21;77(24):11333-8. doi: 10.1021/jo3021314. Epub 2012 Nov 29.
Abstract
We report methods for the synthesis of vertex-differentiated icosahedral closo-boranes. A single B-OH vertex of the icosahedral borane closo-B(12)(OH)(12) was derivatized to prepare closo-B(12)(OR)(OH)(11) using optimized alkylation conditions and purification procedures. Several representative vertex-differentiated icosahedral closo-boranes were prepared utilizing carbonate ester and azide-alkyne click chemistries on the surface of the closo-B(12)(2-) core.
摘要
我们报告了合成顶点差异化的二十面体笼状硼烷的方法。通过优化的烷基化条件和纯化程序，将二十面体硼烷closo-B(12)(OH)(12)的单个 B-OH 顶点衍生化，制备得到closo-B(12)(OR)(OH)(11)。利用碳酸酯酯和叠氮化物-炔点击化学反应，在 closo-B(12)(2-)核心的表面上制备了几种代表性的顶点差异化的二十面体笼状硼烷。
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