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24-和26-高-1,25-二羟基维生素D3类似物：体外骨吸收活性不同于细胞分化活性的报道。

24- and 26-homo-1,25-dihydroxyvitamin D3 analogs: potencies on in vitro bone resorption differ from those reported for cell differentiation.

作者信息

Paulson S K, Perlman K, DeLuca H F, Stern P H

机构信息

Department of Pediatrics, Northwestern University Medical School, Chicago, IL 60611.

出版信息

J Bone Miner Res. 1990 Feb;5(2):201-6. doi: 10.1002/jbmr.5650050214.

DOI:10.1002/jbmr.5650050214
PMID:2316407
Abstract

It has been proposed that the stimulatory effects of 1,25-dihydroxyvitamin D on bone resorption may be mediated through actions on differentiation of marrow cells into monocytic osteoclast precursors. In human promyelocytic leukemia cells (HL-60), 24- and 26-homo-1,25-dihydroxyvitamin D3 and their delta 22 analogs and 24,24-dihomo-1,25-dihydroxyvitamin D3 are 10-fold more potent than 1,25-dihydroxyvitamin D3, and delta 22-24,24,24-trihomo-1,25-dihydroxyvitamin D3 is equipotent with 1,25-dihydroxyvitamin D3 in inducing differentiation into the monocytic phenotype. The effect of these 1,25-dihydroxyvitamin D3 analogous on resorption of fetal rat limb bones in vitro was determined in the present study. 1,25-Dihydroxyvitamin D3 was equipotent with 24-homo-1,25-dihydroxyvitamin D3, delta 22-24-homo-1,25-dihydroxyvitamin D3, 26-homo-1,25-dihydroxyvitamin D3, and delta 22-26-homo-1,25-dihydroxyvitamin D3 for in vitro bone resorption, whereas 24,24-dihomo-1,25-dihydroxyvitamin D3 and delta 22-24,24,24-trihomo-1,25-dihydroxyvitamin D3 were inactive. The failure of these analogs to show a higher bone-resorbing activity than 1,25-dihydroxyvitamin D3 were inactive. The failure of these analogs to show a higher bone-resorbing activity than 1,25-dihydroxyvitamin D3 provides evidence to suggest that the mechanism of 1,25-dihydroxyvitamin D3-induced bone resorption may not involve stimulation of monocytic cell differentiation.

摘要

有人提出，1,25 - 二羟基维生素D对骨吸收的刺激作用可能是通过影响骨髓细胞分化为单核破骨细胞前体来介导的。在人早幼粒细胞白血病细胞（HL - 60）中，24,26 - 同型 - 1,25 - 二羟基维生素D3及其δ22类似物以及24,24 - 二同型 - 1,25 - 二羟基维生素D3诱导分化为单核细胞表型的能力比1,25 - 二羟基维生素D3强10倍，而δ22 - 24,24,24 - 三同型 - 1,25 - 二羟基维生素D3与1,25 - 二羟基维生素D3诱导分化为单核细胞表型的能力相当。本研究测定了这些1,25 - 二羟基维生素D3类似物对体外胎鼠四肢骨吸收的影响。1,25 - 二羟基维生素D3与24 - 同型 - 1,25 - 二羟基维生素D3、δ22 - 24 - 同型 - 1,25 - 二羟基维生素D3、26 - 同型 - 1,25 - 二羟基维生素D3以及δ22 - 26 - 同型 - 1,25 - 二羟基维生素D3在体外骨吸收方面效果相当，而24,24 - 二同型 - 1,25 - 二羟基维生素D3和δ22 - 24,24,24 - 三同型 - 1,25 - 二羟基维生素D3无活性。这些类似物未能表现出比1,25 - 二羟基维生素D3更高的骨吸收活性，这表明1,25 - 二羟基维生素D3诱导骨吸收的机制可能不涉及刺激单核细胞分化。

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引用本文的文献

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Calcif Tissue Int. 1993 Nov;53(5):318-23. doi: 10.1007/BF01351836.