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Lipids. Antibodies against PCSK9--a new era of therapy.

作者信息

King Alexandra

出版信息

Nat Rev Cardiol. 2013 Jan;10(1):1. doi: 10.1038/nrcardio.2012.166. Epub 2012 Nov 20.

DOI:10.1038/nrcardio.2012.166
PMID:23165073
Abstract
摘要

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Lipids. Antibodies against PCSK9--a new era of therapy.脂质。抗前蛋白转化酶枯草溶菌素9型抗体——治疗新时代。
Nat Rev Cardiol. 2013 Jan;10(1):1. doi: 10.1038/nrcardio.2012.166. Epub 2012 Nov 20.
2
Anti-PCSK9 Antibodies: A New Era in the Treatment of Dyslipidemia.抗前蛋白转化酶枯草溶菌素9(PCSK9)抗体:血脂异常治疗的新时代。
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Non-Native Conformational Isomers of the Catalytic Domain of PCSK9 Induce an Immune Response, Reduce Lipids and Increase LDL Receptor Levels.非天然构象同种型的 PCSK9 催化结构域可诱发免疫应答,降低血脂并增加 LDL 受体水平。
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Vasc Health Risk Manag. 2016 May 9;12:185-97. doi: 10.2147/VHRM.S102564. eCollection 2016.
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Real-world study: Escalating targeted lipid-lowering treatment with PCSK9-inhibitors and lipoprotein apheresis.真实世界研究:使用前蛋白转化酶枯草溶菌素9(PCSK9)抑制剂和脂蛋白分离术逐步加强靶向降脂治疗。
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PCSK9 inhibition alters the lipidome of plasma and lipoprotein fractions.PCSK9 抑制改变了血浆和脂蛋白部分的脂质组。
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Proprotein convertase subtilisin/kexin type 9 (PCSK9) inhibitors: Present perspectives and future horizons.前蛋白转化酶枯草溶菌素/克新9型(PCSK9)抑制剂:当前观点与未来展望。
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Increased Plasma PCSK9 Levels Are Associated with Reduced Endotoxin Clearance and the Development of Acute Organ Failures during Sepsis.脓毒症期间血浆前蛋白转化酶枯草溶菌素9(PCSK9)水平升高与内毒素清除减少及急性器官功能衰竭的发生有关。
J Innate Immun. 2016;8(2):211-20. doi: 10.1159/000442976. Epub 2016 Jan 13.
2
PCSK9 is a critical regulator of the innate immune response and septic shock outcome.前蛋白转化酶枯草溶菌素9(PCSK9)是先天性免疫反应和脓毒性休克结局的关键调节因子。
Sci Transl Med. 2014 Oct 15;6(258):258ra143. doi: 10.1126/scitranslmed.3008782.
3
Proprotein convertase subtilisin kexin type 9 promotes intestinal overproduction of triglyceride-rich apolipoprotein B lipoproteins through both low-density lipoprotein receptor-dependent and -independent mechanisms.

本文引用的文献

1
Efficacy, safety, and tolerability of a monoclonal antibody to proprotein convertase subtilisin/kexin type 9 in combination with a statin in patients with hypercholesterolaemia (LAPLACE-TIMI 57): a randomised, placebo-controlled, dose-ranging, phase 2 study.在高胆固醇血症患者中,一种枯草溶菌素/前蛋白转化酶 9 单克隆抗体与他汀类药物联合应用的疗效、安全性和耐受性(LAPLACE-TIMI 57):一项随机、安慰剂对照、剂量范围、2 期研究。
Lancet. 2012 Dec 8;380(9858):2007-17. doi: 10.1016/S0140-6736(12)61770-X. Epub 2012 Nov 6.
2
Efficacy, safety, and tolerability of a monoclonal antibody to proprotein convertase subtilisin/kexin type 9 as monotherapy in patients with hypercholesterolaemia (MENDEL): a randomised, double-blind, placebo-controlled, phase 2 study.在高胆固醇血症患者中单用一种枯草溶菌素转化酶 9 单克隆抗体的疗效、安全性和耐受性(MENDEL):一项随机、双盲、安慰剂对照、2 期研究。
Lancet. 2012 Dec 8;380(9858):1995-2006. doi: 10.1016/S0140-6736(12)61771-1. Epub 2012 Nov 6.
前蛋白转化酶枯草溶菌素9型通过低密度脂蛋白受体依赖和非依赖机制促进肠道中富含甘油三酯的载脂蛋白B脂蛋白的过量产生。
Circulation. 2014 Jul 29;130(5):431-41. doi: 10.1161/CIRCULATIONAHA.113.006720. Epub 2014 May 23.
4
Opening up new fronts in the fight against cholesterol.开辟抗击胆固醇的新战线。
Elife. 2013 Apr 9;2:e00663. doi: 10.7554/eLife.00663.
3
Low-density lipoprotein cholesterol-lowering effects of AMG 145, a monoclonal antibody to proprotein convertase subtilisin/kexin type 9 serine protease in patients with heterozygous familial hypercholesterolemia: the Reduction of LDL-C with PCSK9 Inhibition in Heterozygous Familial Hypercholesterolemia Disorder (RUTHERFORD) randomized trial.载脂蛋白 B 代谢物单克隆抗体 AMG 145 降低杂合子家族性高胆固醇血症患者低密度脂蛋白胆固醇的作用:载脂蛋白 B 代谢物单克隆抗体 AMG 145 降低杂合子家族性高胆固醇血症患者低密度脂蛋白胆固醇的随机试验(RUTHERFORD)
Circulation. 2012 Nov 13;126(20):2408-17. doi: 10.1161/CIRCULATIONAHA.112.144055. Epub 2012 Nov 5.
4
Effect of a monoclonal antibody to PCSK9 on low-density lipoprotein cholesterol levels in statin-intolerant patients: the GAUSS randomized trial.他汀类药物不耐受患者中抗 PCSK9 单克隆抗体对低密度脂蛋白胆固醇水平的影响:GAUSS 随机试验。
JAMA. 2012 Dec 19;308(23):2497-506. doi: 10.1001/jama.2012.25790.
5
Atorvastatin with or without an antibody to PCSK9 in primary hypercholesterolemia.阿托伐他汀联合或不联合抗前蛋白转化酶枯草溶菌素 9 单克隆抗体治疗原发性高胆固醇血症。
N Engl J Med. 2012 Nov 15;367(20):1891-900. doi: 10.1056/NEJMoa1201832. Epub 2012 Oct 31.