环孢素对肾小球功能的体外作用。

In vitro effects of cyclosporine on glomerular function.

作者信息

Wiegmann T B, Sharma R, Diederich D A, Savin V J

机构信息

Kidney and Urology Research Center, University of Kansas Medical Center, Kansas City.

出版信息

Am J Med Sci. 1990 Mar;299(3):149-52. doi: 10.1097/00000441-199003000-00001.

DOI:10.1097/00000441-199003000-00001

PMID:2316558

Abstract

Cyclosporine A (CsA) causes vasoconstriction and decrease in glomerular filtration rate. Experiments were conducted in isolated glomeruli to study effects of CsA of glomerular perfusion and independent of systemic or renal factors. CsA caused a dose dependent decrease in glomerular volume consistent with mesangial contraction. The ultrafiltration coefficient Kf was significantly lower after incubation in 4 X 10(-4) M CsA when compared to control (2.81 +/- 0.2 vs 5.19 +/- 0.5 nl/min X mm Hg; p less than 0.001). Hydraulic conductivity Lp was diminished by CsA from 2.69 +/- 0.11 to 1.41 +/- 0.05 microliter/min X mm Hg X cm2 (p less than 0.001). These findings demonstrate a direct effect of CsA on the glomerulus which must be considered in addition to drug-induced changes in perfusion and tubular function.

摘要

环孢素A（CsA）可引起血管收缩并降低肾小球滤过率。在分离的肾小球中进行了实验，以研究CsA对肾小球灌注的影响，且该影响独立于全身或肾脏因素。CsA导致肾小球体积呈剂量依赖性减小，这与系膜收缩一致。与对照组相比，在4×10⁻⁴ M CsA中孵育后超滤系数Kf显著降低（2.81±0.2对5.19±0.5 nl/min×mmHg；p<0.001）。CsA使水力传导率Lp从2.69±0.11降至1.41±0.05微升/min×mmHg×cm²（p<0.001）。这些发现表明CsA对肾小球有直接作用，除了药物引起的灌注和肾小管功能变化外，这一点也必须予以考虑。