Reams G P
University of Missouri School of Medicine, Department of Medicine, Columbia.
Drugs Aging. 1994 Oct;5(4):263-87. doi: 10.2165/00002512-199405040-00004.
Calcium channel blockers are used in the treatment of hypertension because of their ability to decrease peripheral vascular resistance. Recent research has suggested that these drugs also preserve or improve renal function in patients with essential hypertensive renal disease or diabetic renal disease, and in renal transplant recipients with or without cyclosporin therapy. In general, studies in animal models of hypertension and in hypertensive humans have demonstrated reduction in renal vascular resistance, and preservation or enhancement of renal plasma flow and glomerular filtration rate. In addition, calcium channel blockers appear to have a positive effect on renal addition, calcium channel blockers appear to have a positive effect on renal haemodynamic function in the setting of diabetes mellitus; prospective trials have also demonstrated reductions in urinary protein excretion in these patients. Current evidence suggests that calcium channel blockers are well-suited for the treatment of patients with hypertensive disease even in the presence of renal impairment, a clinical scenario common in the elderly population.
钙通道阻滞剂因其能够降低外周血管阻力而被用于治疗高血压。最近的研究表明，这些药物还能保护或改善原发性高血压肾病或糖尿病肾病患者以及接受或未接受环孢素治疗的肾移植受者的肾功能。一般来说，在高血压动物模型和高血压患者中进行的研究表明，肾血管阻力降低，肾血浆流量和肾小球滤过率得以保留或提高。此外，钙通道阻滞剂似乎对糖尿病患者的肾脏血液动力学功能有积极影响；前瞻性试验也证明这些患者的尿蛋白排泄减少。目前的证据表明，即使存在肾功能损害（这在老年人群中是常见的临床情况），钙通道阻滞剂也非常适合治疗高血压疾病患者。
