Fang Zhao, Sun Tianwei, Yadav Sandip Kumar
Department of Spinal Surgery, Nankai University Affiliated Hospital, Tianjin 300121, PR China.
Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi. 2012 Oct;26(10):1255-8.
To review the research progress of bone morphogenetic protein (BMP) and the liability of ossification of the posterior longitudinal ligament (OPLL).
Recent literature concerning BMP and the liability of OPLL was reviewed, analysed, and summarized.
The single nucleotide polymorphisms (SNPs) of BMP gene may produce a minor cumulative effect and increase individual susceptibility to OPLL. A variety of environmental factors can promote the occurrence and development of OPLL by increasing the expression of BMP gene.
The SNPs of BMP gene may increase individual susceptibility to OPLL. However, interaction of cumulative effect of the SNPs and environmental factors can promote the liability to OPLL.
综述骨形态发生蛋白（BMP）及后纵韧带骨化（OPLL）易感性的研究进展。
对近期有关BMP及OPLL易感性的文献进行回顾、分析和总结。
BMP基因的单核苷酸多态性（SNP）可能产生微小的累积效应，增加个体对OPLL的易感性。多种环境因素可通过增加BMP基因的表达促进OPLL的发生发展。
BMP基因的SNP可能增加个体对OPLL的易感性。然而，SNP的累积效应与环境因素的相互作用可促进OPLL的易感性。
