FoxM1在非小细胞肺癌复发中的作用

Involvement of FoxM1 in non-small cell lung cancer recurrence.

作者信息

Xu Nuo, Wu Sheng-Di, Wang Hao, Wang Qun, Bai Chun-Xue

机构信息

Department of Pulmonary Medicine, Zhongshan Hospital, Fudan University, Shanghai, China.

出版信息

Asian Pac J Cancer Prev. 2012;13(9):4739-43. doi: 10.7314/apjcp.2012.13.9.4739.

DOI:10.7314/apjcp.2012.13.9.4739

PMID:23167412

Abstract

BACKGROUND

Predictive biomarkers for lung cancer recurrence after curative tumor resection remain unclear. This study set out to assess the role of FoxM1 in the recurrence of non-small cell lung cancer.

METHODS

Immunohistochemistry for FoxM1 expression was performed on paraffin-embedded tumor tissues from 165 NSCLC patients. Association of FoxM1 expression with clinicopathological parameters and disease free survival were evaluated.

RESULTS

Our results indicated FoxM1 expression to be significantly associated with poorer tissue differentiation (P =0.03), higher TNM stage (P <0.01), lymph node metastasis (P <0.01), advanced tumor stage (P <0.01), and poorer disease free survival (P <0.01). Multivariable analysis showed that FoxM1 expression increased the hazard of recurrence (hazard ratio= 1.96, 95% CI, 1.04-3.17, P <0.05), indicating that FoxM1 is an independent and significant predictor of lung cancer recurrence.

CONCLUSION

Therefore, FoxM1 is an independent risk factor for recurrence of NSCLC. Elevated FoxM1 expression could be used as an indicator of poor disease free survival.

摘要

背景

根治性肿瘤切除术后肺癌复发的预测生物标志物仍不明确。本研究旨在评估FoxM1在非小细胞肺癌复发中的作用。

方法

对165例非小细胞肺癌患者石蜡包埋的肿瘤组织进行FoxM1表达的免疫组织化学检测。评估FoxM1表达与临床病理参数及无病生存期的相关性。

结果

我们的结果表明，FoxM1表达与较差的组织分化（P = 0.03）、较高的TNM分期（P < 0.01）、淋巴结转移（P < 0.01）、晚期肿瘤分期（P < 0.01）及较差的无病生存期（P < 0.01）显著相关。多变量分析显示，FoxM1表达增加了复发风险（风险比 = 1.96，95% CI，1.04 - 3.17，P < 0.05），表明FoxM1是肺癌复发的独立且重要的预测因子。