Department of Respiratory and Critical Care Medicine, NHC Key Laboratory of Pulmonary Diseases, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, 1277 Jiefang Avenue, Wuhan, 430022, China.
Center for Translational Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, 1277 Jiefang Avenue, Wuhan, 430022, China.
Cell Commun Signal. 2019 Apr 16;17(1):35. doi: 10.1186/s12964-019-0347-1.
Forkhead box M1 (FOXM1), a transcriptional regulator of G1/S and G2/M transition and M phase progression in the cell cycle, plays a principal role in many physiological and pathological processes. A growing number of studies have focused on the relationship between abnormal FOXM1 expression and pulmonary diseases, such as lung cancer, chronic obstructive pulmonary disease (COPD), asthma, acute lung injury (ALI), pulmonary fibrosis, and pulmonary arterial hypertension (PAH). These studies indicate that the FOXM1 regulatory network is a major predictor of poor outcomes, especially in lung cancer, and provide novel insight into various pulmonary diseases. For the first time, this review summarizes the mechanistic relationship between FOXM1 dysregulation and pulmonary diseases, the benefits of targeting abnormal FOXM1 expression, and the questions that remain to be addressed in the future.
叉头框蛋白 M1（FOXM1）是细胞周期中 G1/S 和 G2/M 转换及 M 期进展的转录调节因子，在许多生理和病理过程中发挥主要作用。越来越多的研究集中在异常 FOXM1 表达与肺部疾病之间的关系上，如肺癌、慢性阻塞性肺疾病（COPD）、哮喘、急性肺损伤（ALI）、肺纤维化和肺动脉高压（PAH）。这些研究表明，FOXM1 调控网络是不良预后的主要预测因子，特别是在肺癌中，并为各种肺部疾病提供了新的见解。本文首次总结了 FOXM1 失调与肺部疾病之间的机制关系、针对异常 FOXM1 表达的益处，以及未来需要解决的问题。
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