Jääsaari Päivi, Visnapuu Vivian, Nyström Marjatta, Peltonen Sirkku, Peltonen Juha, Happonen Risto-Pekka
Department of Oral Diseases and Maxillofacial Surgery, University of Turku, Turku, Finland.
Eur J Oral Sci. 2012 Dec;120(6):549-52. doi: 10.1111/j.1600-0722.2012.01000.x. Epub 2012 Oct 4.
Neurofibromatosis type 1 (NF1) is a common, hereditary, neurocutaneous skeletal condition with a variety of osseous manifestations. Although NF1 also affects craniofacial structures, the literature has only limited information related to the effect of NF1 on dental development. In this study the dental age of 34 Finnish NF1 patients, 8-17 yr of age, was estimated using the Demirjian & Goldstein method. The dental age of children with NF1 was similar to that of a Finnish control population. The findings suggest that NF1 does not affect the timing of tooth development.
1型神经纤维瘤病（NF1）是一种常见的遗传性神经皮肤骨骼疾病，有多种骨表现。虽然NF1也会影响颅面结构，但关于NF1对牙齿发育影响的文献资料有限。在本研究中，采用德米尔坚和戈尔茨坦方法对34名年龄在8至17岁的芬兰NF1患者的牙龄进行了评估。NF1患儿的牙龄与芬兰对照人群相似。研究结果表明，NF1不影响牙齿发育的时间。
