2 型糖尿病患者胰岛素剂量的自我调整频率与代谢控制之间的关系——是否存在关联？

Frequency of self-adjustment of insulin dose and metabolic control in Type 2 diabetes -is there an association?

机构信息

Department of Internal Medicine III, Jena University Hospital, Jena, Germany.

出版信息

Diabet Med. 2013 Mar;30(3):e91-4. doi: 10.1111/dme.12071.

DOI:10.1111/dme.12071

PMID:23167905

Abstract

AIM

To investigate the supposition that self-adjustment of insulin dose will improve metabolic control in patients with Type 2 diabetes.

METHODS

The number of self-adjustments of insulin dose was checked in a cross-sectional study involving 300 patients with Type 2 diabetes in a university outpatient department, who were insulin treated.

RESULTS

One hundred and ninety-three patients (64%) performed insulin dose adjustments at least once in 14 days. The mean number of dose adjustments was 17.4 per 14 days. Patients with self-adjustments of insulin dose were younger (65.6 vs. 68.9 years), had a higher social status score (11.1 vs. 9.8) and a higher insulin dose (68.8 vs. 53.6 IU/day) than patients without dose adjustments. Each insulin dose adjustment was associated with an HbA(1c) decrease of 0.016% (P = 0.004). Any additional blood glucose self measurement was associated with an HbA(1c) increase of 0.019% (P = 0.038).

CONCLUSIONS

Two-thirds of patients with Type 2 diabetes, who have undergone training in how to manage their condition, practise insulin dose self-adjustments. A weak association was observed between insulin dose adjustments and HbA(1c).

摘要

目的

调查关于自行调整胰岛素剂量可以改善 2 型糖尿病患者代谢控制的假设。

方法

通过横断面研究，检查了 300 名在大学门诊接受胰岛素治疗的 2 型糖尿病患者的胰岛素剂量自行调整次数。

结果

193 名（64%）患者在 14 天内至少进行了一次胰岛素剂量调整。平均每 14 天调整 17.4 次剂量。与未调整剂量的患者相比，进行胰岛素剂量调整的患者年龄更小（65.6 岁 vs. 68.9 岁），社会地位评分更高（11.1 分 vs. 9.8 分），胰岛素剂量更高（68.8IU/天 vs. 53.6IU/天）。每次胰岛素剂量调整与 HbA1c 降低 0.016%相关（P=0.004）。任何额外的血糖自我监测与 HbA1c 升高 0.019%相关（P=0.038）。