一项基于问卷的调查，旨在评估患者对 follitropin-alpha（Gonal-f）按质量填充（FbM）预充笔的满意度、学习易用性、使用易用性、注射部位疼痛以及总体患者满意度，与其他促性腺激素给药系统进行比较。

A questionnaire-based survey to assess patient satisfaction, ease-of-learning, ease-of-use, injection site pain and overall patient satisfaction of the follitropin-alpha (Gonal-f) filled-by-mass (FbM) prefilled pen compared with other systems of gonadotrophin administration.

机构信息

Japanese Institution for Standardizing Assisted Reproductive Technology, Osaka, Japan.

出版信息

Reprod Biol Endocrinol. 2012 Nov 20;10:93. doi: 10.1186/1477-7827-10-93.

DOI:10.1186/1477-7827-10-93

PMID:23167906

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3567994/

Abstract

BACKGROUND

Gonadotrophins are used routinely for follicular stimulation during ovarian induction and assisted reproduction techniques. Developments in recombinant follicle-stimulating hormone preparations and their injection devices have improved patient quality of life by enabling patients to self-administer treatment at home. The objective of this study was to investigate patient experiences of learning to use and overall satisfaction with the follitropin-alpha (Gonal-f) filled-by-mass (FbM) prefilled pen.

METHODS

This questionnaire-based survey study was conducted in 23 fertility centres in Japan over a period of 14 months. Patients who were receiving fertility treatment with the follitropin-alpha (FbM) prefilled pen were asked to complete a questionnaire to assess their satisfaction, ease of learning and use, and injection site pain following treatment.

RESULTS

A total of 663 women participated in the study. The majority of patients found the instructions for administering follitropin-alpha with the prefilled pen easy to understand (83.0%; n = 546/658) and patients found that a hands-on demonstration by a nurse or doctor was the most useful tool for learning to use the follitropin-alpha (FbM) prefilled pen (80.0%; n = 497/621). Forty-eight percent (n = 318) of patients in the study had previous experience with different types of fertility medications and the majority of these patients found the follitropin-alpha (FbM) prefilled pen easier to use (75.1%; n = 232/309) and less painful (89.0%; n = 347/390) than their previous medication. The majority (80.2%; n = 521/650) of patients reported overall satisfaction with the follitropin-alpha (FbM) prefilled pen.

CONCLUSIONS

The follitropin-alpha (FbM) prefilled pen is an easy-to-use injection device according to this questionnaire-based survey. Patients who had experience of different types of fertility medication preferred the follitropin-alpha (FbM) prefilled pen to other injection devices.

摘要

背景

促性腺激素在卵巢诱导和辅助生殖技术中常规用于卵泡刺激。重组卵泡刺激素制剂及其注射装置的发展通过使患者能够在家中自行治疗，提高了患者的生活质量。本研究的目的是调查患者学习使用和对 follitropin-alpha（Gonal-f）填充质量（FbM）预填充笔的总体满意度的经验。

方法

这项基于问卷调查的研究在日本的 23 个生育中心进行了 14 个月。正在接受 follitropin-alpha（FbM）预填充笔治疗的患者被要求填写一份问卷，以评估他们的满意度、学习和使用的便利性以及治疗后的注射部位疼痛。

结果

共有 663 名女性参与了这项研究。大多数患者发现使用预填充笔给予 follitropin-alpha 的说明易于理解（83.0%；n=546/658），并且患者发现护士或医生的实际操作演示是学习使用 follitropin-alpha（FbM）预填充笔的最有用工具（80.0%；n=497/621）。研究中有 48%（n=318）的患者以前有过不同类型的生育药物治疗经验，其中大多数患者发现 follitropin-alpha（FbM）预填充笔更容易使用（75.1%；n=232/309）且疼痛程度较低（89.0%；n=347/390）比他们以前的药物。大多数（80.2%；n=521/650）患者对 follitropin-alpha（FbM）预填充笔总体满意。