Luo Zhu-ron, Xie Qin-jing
Department of Cardiology, PLA Fuzhou General Hospital, Fuzhou 350025, Fujian, China.
Zhongguo Wei Zhong Bing Ji Jiu Yi Xue. 2012 Dec;24(12):730-3.
To explore the association of osteoprotegerin (OPG) gene polymorphisms 209G/A, 245T/G and 1181G/C in the Han population of Fujian province with acute coronary syndrome (ACS) and its severity.
A prospective study was conducted. Two hundred and fifty-two cases without sibship of Fujian Han people was enrolled from July 2010 to September 2011, in which 68 healthy subjects as controls. One hundred and eighty-four patients with ACS were divided into three groups, 60 had one-vessel, 68 had two-vessel, and 54 had three-vessel lesion, 2 had not been found stenosis. DNA was extracted from venous blood, different groups of OPG gene polymorphism was identified by Sanger Method. OPG 209G/A, 245T/G and 1181G/C genotype frequencies and allelic frequencies were analyzed between ACS subjects and normal subjects and among the three groups of ACS, and the relationship between gene polymorphisms and ACS severity.
No significant differences were observed in the genotype and allelic frequencies of OPG gene 209G/A, 245T/G between the ACS and control groups. Significant differences were observed in the genotype and allelic frequencies of OPG gene 1181G/C between the ACS and control groups [1181G/C GG: 92 (50.0%) vs. 43 (63.2%), CC: 26 (14.1%) vs. 0, GC: 66 (35.9%) vs. 25 (36.8%), χ(2)=11.240, P=0.004; allelic gene G: 250 (67.9%) vs. 111 (81.6%), allelic gene C: 118 (32.1%) vs. 25 (18.4%), χ(2)=9.148, P=0.002]. No significant differences were observed in the genotype and allelic frequencies of OPG gene 209G/A, 245T/G and 1181G/C between those groups.
There were no significant difference in frequencies OPG genotype and allele in polymorphisms 209G/A, 245T/C between patients with ACS and control group in Han population of Fujian province. There were difference in frequencies OPG genotype and allele in polymorphisms 1181G/C between patients with ACS and control group, but it was not differently distributed among patients with single-, double-, or triple-vessel lesion.
探讨福建省汉族人群骨保护素（OPG）基因209G/A、245T/G和1181G/C多态性与急性冠脉综合征（ACS）及其严重程度的关系。
进行一项前瞻性研究。2010年7月至2011年9月纳入252例无血缘关系的福建汉族人，其中68例健康受试者作为对照。184例ACS患者分为三组，60例单支血管病变，68例双支血管病变，54例三支血管病变，2例未发现狭窄。从静脉血中提取DNA，采用桑格法鉴定OPG基因多态性的不同组。分析ACS患者与正常受试者之间以及ACS三组之间OPG 209G/A、245T/G和1181G/C基因型频率和等位基因频率，以及基因多态性与ACS严重程度的关系。
ACS组与对照组之间OPG基因209G/A、245T/G的基因型和等位基因频率无显著差异。ACS组与对照组之间OPG基因1...
福建省汉族人群中，ACS患者与对照组之间OPG基因多态性209G/A、245T/C的基因型和等位基因频率无显著差异。ACS患者与对照组之间OPG基因多态性1181G/C的基因型和等位基因频率存在差异，但在单支、双支或三支血管病变患者中分布无差异。 （注：原文中“1181G/C”部分的表述存在重复且不完整的情况，翻译时尽量按照原文呈现的信息进行了翻译）
