Department of Vascular Medicine, University Medical Center Utrecht, Utrecht, the Netherlands.
Menopause. 2013 Apr;20(4):409-17. doi: 10.1097/gme.0b013e31827212a5.
The aim of this study was to determine the effect of sex and the menopausal transition on age-related differences in visceral adipose tissue (VAT) and subcutaneous adipose tissue (SAT) among patients with cardiovascular disease.
A cross-sectional study of 997 women and 3,409 men with cardiovascular disease was performed. VAT and SAT were measured by ultrasonography. Differences in abdominal fat per decade in premenopausal and postmenopausal women were analyzed with linear regression and compared with men younger and older than the mean menopause age of women.
VAT increased gradually across advancing age groups. For postmenopausal women, the 10-year differences in VAT were smaller than those for premenopausal women (0.24 cm [β = 0.24; 95% CI, 0.05 to 0.43] vs 0.71 cm [β = 0.71; 95% CI, 0.29 to 1.12]). There were no differences in SAT (β = -0.12; 95% CI, -0.37 to 0.13) in premenopausal women, and SAT decreased across the age groups of postmenopausal women (-0.36 cm per decade [β = -0.36; 95% CI, -0.47 to -0.26]). Postmenopausal women showed 10-year differences in VAT that were larger than those for men 48 years or older (0.24 cm per decade [β = 0.24; 95% CI, 0.05 to 0.43] vs -0.01 cm per decade [β = -0.01; 95% CI, -0.12 to 0.10]). In addition, 10-year differences in SAT were larger in postmenopausal women than in men 48 years or older (-0.36 cm [β = -0.36; 95% CI, -0.47 to -0.26] vs -0.22 cm [β = -0.22; 95% CI, -0.27 to -0.18]).
Menopause is not associated with accelerated fat gain in women with cardiovascular disease. Compared with similar-aged men, postmenopausal women show a steeper increase in VAT and a steeper decrease in SAT. These ongoing changes might add to an unfavorable metabolic profile associated with an increased risk of recurrent cardiovascular events.
本研究旨在确定性别和绝经过渡对心血管疾病患者中与年龄相关的内脏脂肪组织(VAT)和皮下脂肪组织(SAT)差异的影响。
对 997 名女性和 3409 名男性进行了一项横断面研究。通过超声测量 VAT 和 SAT。用线性回归分析绝经前和绝经后女性每十年腹部脂肪的差异,并与绝经后女性平均绝经年龄大于或小于该年龄的男性进行比较。
VAT 随年龄组逐渐增加。对于绝经后女性,VAT 的 10 年差异小于绝经前女性(0.24cm[β=0.24;95%CI,0.05 至 0.43]vs 0.71cm[β=0.71;95%CI,0.29 至 1.12])。绝经前女性 SAT 无差异(β=-0.12;95%CI,-0.37 至 0.13),而绝经后女性 SAT 随年龄组减少(每十年减少 0.36cm[β=-0.36;95%CI,-0.47 至 -0.26])。绝经后女性 VAT 的 10 年差异大于 48 岁或以上男性(每十年增加 0.24cm[β=0.24;95%CI,0.05 至 0.43]vs 每十年减少 0.01cm[β=-0.01;95%CI,-0.12 至 0.10])。此外,绝经后女性 SAT 的 10 年差异大于 48 岁或以上男性(-0.36cm[β=-0.36;95%CI,-0.47 至 -0.26]vs-0.22cm[β=-0.22;95%CI,-0.27 至 -0.18])。
绝经与心血管疾病女性的脂肪加速增长无关。与同龄男性相比,绝经后女性 VAT 增加更陡峭,SAT 减少更陡峭。这些持续的变化可能会导致代谢谱不利,增加复发性心血管事件的风险。