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[2006年至2010年间入住切拉尔·拜亚尔大学医院医学寄生虫学实验室的疑似弓形虫病患者血清学结果评估]

[Evaluation of serological results of patients with suspected Toxoplasmosis admitted to the medical parasitology laboratory of Celal Bayar University Hospital between 2006-2010].

作者信息

Bölük Selin, Ozyurt Beyhan Cengiz, Girginkardeşler Nogay, Kilimcioğlu Ali Ahmet

机构信息

Celal Bayar Üniversitesi Sağlık Bilimleri Enstitüsü, Tıbbi Parazitoloji Anabilim Dalı, Manisa, Türkiye.

出版信息

Turkiye Parazitol Derg. 2012;36(3):137-41. doi: 10.5152/tpd.2012.33.

DOI:10.5152/tpd.2012.33
PMID:23169155
Abstract

OBJECTIVE

The aim of this study is to determine the serological results of patients with suspected toxoplasmosis who were admitted to the Medical Parasitology Laboratory of Celal Bayar University Hospital in Manisa between 2006 and 2010.

METHODS

Anti-Toxoplasma gondii IgG and IgM antibodies were investigated by IFAT, IgG ELISA, and IgM Capture ELISA in 2815 patients. IgG avidity tests were also performed in cases with both IgG and IgM seropositivity.

RESULTS

Only IgG, only IgM and both IgG and IgM seropositivity were detected in 657 (23.3%), 4 (0.1%) and 6 (0.2%) cases respectively among 2815 patients. Anti-T. gondii IgG seropositivity was mostly found in patients [21.2% (n=139)] who consume raw meat. IgG seroprevalence was found to be statistically higher in the 15-49 age group than the 0-14 age group (p < 0.05). Decrease in the prevalence of anti- T. gondii IgG seropositivity in 2010 was found to be statistically significant considering the five years period (p < 0.001).

CONCLUSION

Raw meat consumption was detected as the most important risk factor in Toxoplasma infection. A decrease in anti-T. gondii IgG antibodies was detected in recent years considering the five years' serologic data, but toxoplasmosis remains important as a public health problem in Manisa.

摘要

目的

本研究旨在确定2006年至2010年期间入住马尼萨市切拉尔·巴亚尔大学医院医学寄生虫学实验室的疑似弓形虫病患者的血清学检测结果。

方法

采用间接荧光抗体试验(IFAT)、IgG酶联免疫吸附测定(ELISA)和IgM捕获ELISA对2815例患者的抗弓形虫IgG和IgM抗体进行检测。对IgG和IgM血清学均呈阳性的病例还进行了IgG亲和力检测。

结果

在2815例患者中,分别有657例(23.3%)仅IgG呈阳性,4例(0.1%)仅IgM呈阳性,6例(0.2%)IgG和IgM均呈阳性。抗弓形虫IgG血清学阳性主要见于食用生肉的患者[21.2%(n = 139)]。IgG血清阳性率在15 - 49岁年龄组中显著高于0 - 14岁年龄组(p < 0.05)。考虑到五年的时间跨度,2010年抗弓形虫IgG血清学阳性率的下降具有统计学意义(p < 0.001)。

结论

食用生肉被检测为弓形虫感染的最重要危险因素。根据五年的血清学数据,近年来检测到抗弓形虫IgG抗体有所下降,但弓形虫病在马尼萨市作为一个公共卫生问题仍然很重要。

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