全球肠道多中心研究（GEMS）中的统计方法。
Statistical methods in the Global Enteric Multicenter Study (GEMS).
机构信息
Center for Vaccine Development, University of Maryland School of Medicine, 685 W Baltimore St, Baltimore, MD 21201, USA.
出版信息
Clin Infect Dis. 2012 Dec;55 Suppl 4(Suppl 4):S246-53. doi: 10.1093/cid/cis788.
Abstract
The Global Enteric Multicenter Study (GEMS) is an investigation of the burden (number of cases and incidence) of moderate-to-severe diarrhea (MSD) in children <60 months of age at 7 sites in sub-Saharan Africa and South Asia. The population attributable fraction for a putative pathogen, either unadjusted or adjusted for other pathogens, is estimated using the proportion of MSD cases from whom the pathogen was isolated and the odds ratio for MSD and the pathogen from conditional logistic regression modeling. The adjusted attributable fraction, proportion of MSD cases taken to a sentinel health center (SHC), number of cases presenting to an SHC, and the site's population are used to estimate the annual number of MSD cases and MSD incidence rate attributable to a pathogen or group of pathogens. Associations with death and nutritional outcomes, ascertained at follow-up visits to case and control households, are evaluated both in MSD cases and in the population.
摘要
全球肠道疾病研究（GEMS）是对撒哈拉以南非洲和南亚 7 个地点 60 个月以下儿童中中度至重度腹泻（MSD）的负担（病例数和发病率）的调查。使用从疑似病原体分离出的 MSD 病例的比例和条件逻辑回归建模的 MSD 和病原体的优势比来估计未经调整或调整其他病原体后的归因分数。调整后的归因分数、送往哨点保健中心（SHC）的 MSD 病例比例、到 SHC 就诊的病例数以及该地点的人口，用于估计归因于病原体或病原体组的 MSD 病例数和 MSD 发病率。在病例和对照家庭的随访中确定的与死亡和营养结果的关联，在 MSD 病例和人群中均进行了评估。
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