Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.
N Engl J Med. 2012 Nov 22;367(21):2006-14. doi: 10.1056/NEJMoa1203241.
Attention deficit-hyperactivity disorder (ADHD) is a common disorder that has been associated with criminal behavior in some studies. Pharmacologic treatment is available for ADHD and may reduce the risk of criminality.
Using Swedish national registers, we gathered information on 25,656 patients with a diagnosis of ADHD, their pharmacologic treatment, and subsequent criminal convictions in Sweden from 2006 through 2009. We used stratified Cox regression analyses to compare the rate of criminality while the patients were receiving ADHD medication, as compared with the rate for the same patients while not receiving medication.
As compared with nonmedication periods, among patients receiving ADHD medication, there was a significant reduction of 32% in the criminality rate for men (adjusted hazard ratio, 0.68; 95% confidence interval [CI], 0.63 to 0.73) and 41% for women (hazard ratio, 0.59; 95% CI, 0.50 to 0.70). The rate reduction remained between 17% and 46% in sensitivity analyses among men, with factors that included different types of drugs (e.g., stimulant vs. nonstimulant) and outcomes (e.g., type of crime).
Among patients with ADHD, rates of criminality were lower during periods when they were receiving ADHD medication. These findings raise the possibility that the use of medication reduces the risk of criminality among patients with ADHD. (Funded by the Swedish Research Council and others.).
注意力缺陷多动障碍(ADHD)是一种常见疾病,一些研究表明其与犯罪行为有关。ADHD 可通过药物治疗,且可能降低犯罪风险。
我们利用瑞典全国登记处的数据,收集了 2006 年至 2009 年间瑞典 25656 例 ADHD 患者的诊断、药物治疗和随后的犯罪记录。我们采用分层 Cox 回归分析比较了患者接受 ADHD 药物治疗和未接受药物治疗期间的犯罪率。
与未用药期间相比,接受 ADHD 药物治疗的男性犯罪率显著降低 32%(调整后的危险比为 0.68;95%置信区间为 0.63 至 0.73),女性降低 41%(危险比为 0.59;95%置信区间为 0.50 至 0.70)。在男性中进行的敏感性分析中,药物治疗的犯罪率降低率在 17%至 46%之间,其中包括不同类型的药物(如兴奋剂与非兴奋剂)和结果(如犯罪类型)等因素。
在 ADHD 患者中,接受 ADHD 药物治疗期间犯罪率较低。这些发现提示药物治疗可能降低 ADHD 患者的犯罪风险。(由瑞典研究理事会和其他机构资助)。