在存在酰基辅酶A：胆固醇酰基转移酶抑制剂（山道士58 - 035）的情况下，巨噬细胞中富含油酸的胆固醇酯被乙酰低密度脂蛋白蓄积。
Accumulation of oleate-rich cholesteryl esters by acetyl-LDL in macrophages in the presence of an acyl-CoA: cholesterol acyltransferase inhibitor (Sandoz 58-035).
作者信息
Shimasaki O, Mineo C, Mowri H, Ohkuma S, Takano T
机构信息
Department of Microbiology and Molecular Pathology, Faculty of Pharmaceutical Sciences, Teikyo University, Kanagawa, Japan.
出版信息
Biochem Int. 1990;20(2):389-96.
The mechanism through which cholesteryl esters rich in oleic acid accumulate in the cytoplasm was studied. The fatty acid composition of the cholesteryl esters in acetyl-LDL was high in linoleic acid, while that of cholesteryl ester inclusion bodies accumulated in the cytoplasm was high in oleic acid. This compositional change of fatty acids in cholesteryl esters occurred even in the presence of an acyl-CoA: cholesterol acyltransferase (ACAT) inhibitor, Sandoz 58-035. These results suggest that oleate-rich cholesteryl esters accumulated in the cytoplasm, even though the reesterification in microsome was inhibited by an ACAT inhibitor.
对富含油酸的胆固醇酯在细胞质中积累的机制进行了研究。乙酰低密度脂蛋白中胆固醇酯的脂肪酸组成富含亚油酸，而细胞质中积累的胆固醇酯包涵体的脂肪酸组成则富含油酸。即使存在酰基辅酶A：胆固醇酰基转移酶（ACAT）抑制剂桑多斯58-035，胆固醇酯中脂肪酸的这种组成变化仍然发生。这些结果表明，即使微粒体中的再酯化作用被ACAT抑制剂抑制，富含油酸的胆固醇酯仍会在细胞质中积累。
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