Dixit V M, Hettiaratchi E S
Med Hypotheses. 1979 Dec;5(12):1327-31. doi: 10.1016/0306-9877(79)90102-6.
The mechanism of hyperlipidaemia in the nephrotic syndrome has not been fully established. We propose that it results from hypoalbuminaemia due to inhibition of the reaction catalysed by lecithin cholesterol acyltransferase converting cholesterol of high density lipoproteins to cholesterol esters and to an inhibition of high density lipoprotein particle formation from very low density lipoproteins due to reduced activity of lipoprotein lipase.
肾病综合征中高脂血症的机制尚未完全明确。我们认为，它是由低白蛋白血症导致的，低白蛋白血症是由于卵磷脂胆固醇酰基转移酶催化的反应受到抑制，该反应将高密度脂蛋白中的胆固醇转化为胆固醇酯，同时也是由于脂蛋白脂肪酶活性降低，抑制了极低密度脂蛋白形成高密度脂蛋白颗粒。
