缺氧诱导因子-1 作为癌症治疗靶点。
Hypoxia-inducible factor-1 as a therapeutic target in cancer.
机构信息
Institute of Digestive Disease, Department of Medicine and Therapeutics, Li Ka Shing Institute of Health Sciences, The Chinese University of Hong Kong.
出版信息
J Gastroenterol Hepatol. 2013 Mar;28(3):401-5. doi: 10.1111/jgh.12038.
Hypoxia-inducible factor-1 (HIF-1) is a transcription factor that immortalizes tumors by inducing key genes in cancer biology, including angiogenesis, glycolysis, invasion, and metastasis. Overexpression of HIF-1α is thus associated with resistance to cancer chemotherapy and increased patient mortality in several cancer phenotypes. In the present review, we summarize the role of intratumoral hypoxia and bioactive lipids in enhancing HIF-1 activity, critically discussing the potential for HIF-1α inhibitors in cancer chemotherapy. Considering preclinical studies, HIF-1 inhibitors appear to have antitumor effects and thus represent a novel therapeutic strategy.
缺氧诱导因子-1（HIF-1）是一种转录因子，通过诱导癌症生物学中的关键基因，包括血管生成、糖酵解、侵袭和转移，使肿瘤永生化。因此，HIF-1α 的过表达与几种癌症表型的癌症化疗耐药性和患者死亡率增加有关。在本综述中，我们总结了肿瘤内缺氧和生物活性脂质在增强 HIF-1 活性中的作用，批判性地讨论了 HIF-1α 抑制剂在癌症化疗中的潜力。考虑到临床前研究，HIF-1 抑制剂似乎具有抗肿瘤作用，因此代表了一种新的治疗策略。
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