Giesen H K, Fryda-Kaurimsky Z
Med Klin. 1979 Oct 19;74(42):1553-6.
12 patients with bronchial asthma received treatment with Ketotifen for three months. 8 patients then continued this medication for at least 9 months. During this period it was possible to reduce the amount of theophylline and bronchodilator amines as well as the maintenance dose of corticosteroids. Afterwards 6 patients showed clinical deterioration while on placebo; this was considered further evidence of the anti-asthmatic effect of Ketotifen. Ketotifen seems to be acceptable as a prophylactic agent in asthma.
12例支气管哮喘患者接受了酮替芬治疗3个月。其中8例患者随后继续使用该药物至少9个月。在此期间,有可能减少茶碱和支气管扩张剂胺的用量以及皮质类固醇的维持剂量。之后,6例患者在服用安慰剂时出现临床病情恶化;这被视为酮替芬抗哮喘作用的进一步证据。酮替芬似乎可作为哮喘的预防药物。