Department of Pediatrics II, Medical University of Innsbruck, Innsbruck, Austria.
Pediatr Res. 2013 Feb;73(2):226-35. doi: 10.1038/pr.2012.171. Epub 2012 Nov 22.
In preterm infants, the amplitude-integrated electroencephalogram (aEEG) is not established in clinical routine. The aim of this study was to derive normative data on aEEG parameters by means of longitudinal characterization and to evaluate the impact of gestational age (GA), postnatal age (PNA), postmenstrual age, sedation, and patent ductus arteriosus (PDA).
Recordings from 61 infants with GA 28-31 weeks were obtained during the first 72 h, then weekly until the age of 4 wk. Infants were divided into three groups: (i) no sedation, no PDA, (ii) sedation, no PDA, and (iii) sedation, PDA. Assessed parameters included background activity, cycling, amplitude, and log ratio of the maximum/minimum amplitude.
GA and PNA had a significant impact within 72 h. Sedation modified aEEG, and presence of PDA was associated with reduced aEEG scores within 72 h. The log ratio of the amplitude correlated with GA but was unaffected by sedation and PDA.
Evaluation of electrocortical background activity within the first postnatal hours and longitudinally over days and weeks is important to better understand the postnatal factors impacting cerebral function in preterm infants. There is a need to agree on definitions and a standardized reporting system in order to permit comparisons between studies and establish aEEG as a method for routine monitoring of preterm infants.
在早产儿中，振幅整合脑电图（aEEG）尚未在临床常规中建立。本研究旨在通过纵向特征描述得出 aEEG 参数的正常数据，并评估胎龄（GA）、生后年龄（PNA）、校正胎龄、镇静和动脉导管未闭（PDA）的影响。
对 61 名胎龄 28-31 周的婴儿在出生后第 1 天至第 72 小时内进行记录，之后每周记录一次，直到 4 周龄。将婴儿分为三组：（i）无镇静，无 PDA；（ii）镇静，无 PDA；（iii）镇静，PDA。评估的参数包括背景活动、周期性、振幅和最大/最小振幅的对数比。
GA 和 PNA 在 72 小时内有显著影响。镇静改变了 aEEG，PDA 的存在与 72 小时内 aEEG 评分降低有关。振幅的对数比与 GA 相关，但不受镇静和 PDA 的影响。
在出生后最初几小时内评估皮质电活动，并在数天和数周内进行纵向评估，对于更好地了解影响早产儿脑功能的产后因素非常重要。需要就定义和标准化报告系统达成一致，以便能够在研究之间进行比较，并将 aEEG 确立为监测早产儿的常规方法。
