自身免疫性甲状腺疾病作为慢性特发性荨麻疹患者血管性水肿的危险因素：一项病例对照研究。

Autoimmune thyroid disease as a risk factor for angioedema in patients with chronic idiopathic urticaria: a case-control study.

作者信息

Missaka Ruy Felippe Brito Gonçalves, Penatti Henrique Costa, Silvares Maria Regina Cavariani, Nogueira Célia Regina, Mazeto Gláucia Maria Ferreira da Silva

机构信息

Department of Dermatology and Radiotherapy, Botucatu Medical School, Universidade Estadual Paulista, Botucatu, São Paulo, Brazil.

出版信息

Sao Paulo Med J. 2012;130(5):294-8. doi: 10.1590/s1516-31802012000500005.

DOI:10.1590/s1516-31802012000500005

PMID:23174868

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10836470/

Abstract

CONTEXT AND OBJECTIVE

An association between chronic idiopathic urticaria (CIU) and autoimmune thyroid disease (ATD) has been reported. However, there have not been any reports on whether ATD raises the risk of angioedema, which is a more severe clinical presentation of CIU. Thus, the aim of the present study was to evaluate whether the risk of angioedema is increased in patients with CIU and ATD.

DESIGN AND SETTING

Case-control study including 115 patients with CIU at a tertiary public institution.

METHODS

The patients were evaluated with regard to occurrence of angioedema and presence of ATD, hypothyroidism or hyperthyroidism.

RESULTS

Angioedema was detected in 70 patients (60.9%). There were 22 cases (19.1%) of ATD, 19 (16.5%) of hypothyroidism and nine (7.8%) of hyperthyroidism. The risk among patients with ATD was 16.2 times greater than among those without this thyroid abnormality (confidence interval, CI = 2.07-126.86). The odds ratio for hypothyroidism was 4.6 (CI = 1.00-21.54) and, for hyperthyroidism, 3.3 (CI = 0.38-28.36).

CONCLUSIONS

Patients with CIU and ATD presented greater risk of angioedema, which reinforces the idea that a relationship exists between this allergic condition and thyroid autoimmunity. This finding could imply that such patients require specifically directed therapy.

摘要

背景与目的

已有报道称慢性特发性荨麻疹（CIU）与自身免疫性甲状腺疾病（ATD）之间存在关联。然而，关于ATD是否会增加血管性水肿（CIU的一种更严重临床表现）的风险，尚无任何报道。因此，本研究的目的是评估CIU合并ATD患者发生血管性水肿的风险是否增加。

设计与研究地点

在一家三级公立医院对115例CIU患者进行病例对照研究。

方法

对患者的血管性水肿发生情况以及ATD、甲状腺功能减退或甲状腺功能亢进的存在情况进行评估。

结果

70例患者（60.9%）检测到血管性水肿。有22例（19.1%）ATD、19例（16.5%）甲状腺功能减退和9例（7.8%）甲状腺功能亢进。ATD患者的风险比无此甲状腺异常的患者高16.2倍（置信区间，CI = 2.07 - 126.86）。甲状腺功能减退的优势比为4.6（CI = 1.00 - 21.54），甲状腺功能亢进的优势比为3.3（CI = 0.38 - 28.36）。